Nt5c2 5'-nucleotidase, cytosolic II [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nt5c2provided by RGD
Official Full Name: 5'-nucleotidase, cytosolic IIprovided by RGD
Primary source: RGD:2323387
See related: EnsemblRapid:ENSRNOG00000020179 AllianceGenome:RGD:2323387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GMP 5'-nucleotidase activity and IMP 5'-nucleotidase activity. Involved in adenosine metabolic process and purine nucleoside monophosphate metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 161.8), Adrenal (RPKM 113.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (255712797..255838285, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (245770993..245896925, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (266652966..266782935, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU028631 (e-PCR)
- UniSTS:112140

AU046797 (e-PCR)
- UniSTS:111125

RH138834 (e-PCR)
- UniSTS:220921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-nucleotidase activity	IEA Inferred from Electronic Annotation more info
enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GMP 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables GMP 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables IMP 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables IMP 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleoside phosphotransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside phosphotransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in GMP catabolic process to guanine	ISO Inferred from Sequence Orthology more info
involved_in GMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in GMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in IMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in IMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dGMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytosolic purine 5'-nucleotidase

Names: cytosolic nucleoside phosphotransferase 5'N

NP_001388640.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_002728937.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_038957357.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_038957358.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_038957359.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_038957360.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

XP_063138838.1

EC 2.7.1.77

EC 3.1.3.5

EC 3.1.3.99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401711.1 → NP_001388640.1 cytosolic purine 5'-nucleotidase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

D3ZMY7

UniProtKB/TrEMBL

A0A8L2QH70, A6JHP1

Related

ENSRNOP00000080847.2, ENSRNOT00000109706.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

255712797..255838285 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002728891.7 → XP_002728937.1 cytosolic purine 5'-nucleotidase isoform X2

See identical proteins and their annotated locations for XP_002728937.1

UniProtKB/TrEMBL

A0A8I6A978, A0A8I6GLV2

Related

ENSRNOP00000096997.1, ENSRNOT00000103587.2

Conserved Domains (1) summary

pfam05761
Location:69 → 514

5_nucleotid; 5' nucleotidase family
XM_063282768.1 → XP_063138838.1 cytosolic purine 5'-nucleotidase isoform X1

UniProtKB/Swiss-Prot

D3ZMY7

UniProtKB/TrEMBL

A0A8L2QH70, A6JHP1
XM_039101430.2 → XP_038957358.1 cytosolic purine 5'-nucleotidase isoform X1

UniProtKB/Swiss-Prot

D3ZMY7

UniProtKB/TrEMBL

A0A8L2QH70, A6JHP1

Conserved Domains (1) summary

pfam05761
Location:43 → 488

5_nucleotid; 5' nucleotidase family
XM_039101429.2 → XP_038957357.1 cytosolic purine 5'-nucleotidase isoform X1

UniProtKB/Swiss-Prot

D3ZMY7

UniProtKB/TrEMBL

A0A8L2QH70, A6JHP1

Conserved Domains (1) summary

pfam05761
Location:43 → 488

5_nucleotid; 5' nucleotidase family
XM_039101431.2 → XP_038957359.1 cytosolic purine 5'-nucleotidase isoform X3

Conserved Domains (1) summary

cl17687
Location:1 → 297

5_nucleotid; 5' nucleotidase family
XM_039101432.2 → XP_038957360.1 cytosolic purine 5'-nucleotidase isoform X3

Conserved Domains (1) summary

cl17687
Location:1 → 297

5_nucleotid; 5' nucleotidase family