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    Rspo2 R-spondin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rspo2provided by RGD
    Official Full Name
    R-spondin 2provided by RGD
    Primary source
    RGD:1562331
    See related
    EnsemblRapid:ENSRNOG00000037687 AllianceGenome:RGD:1562331
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562331
    Summary
    Predicted to enable BMP receptor binding activity and heparin binding activity. Predicted to be involved in limb development and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; and respiratory system development. Predicted to be located in cell surface and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 16.5), Lung (RPKM 2.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rspo2 in Genome Data Viewer
    Location:
    7q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (75987217..76123984, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (74096378..74239398, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (81919911..82059659, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479718 Neighboring gene U7 small nuclear RNA Neighboring gene eukaryotic translation initiation factor 3 subunit E Neighboring gene mortality factor 4 like 1, pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Early region-specific gene expression during tract formation in the embryonic rat forebrain. Hatanaka Y, et al. J Comp Neurol, 1998 Jun 8. PMID 9596525
    2. A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals. Hsu PJ, et al. PLoS One, 2014. PMID 25188337, Free PMC Article
    3. R-spondins/Lgrs expression in tooth development. Kawasaki M, et al. Dev Dyn, 2014 Jun. PMID 24616052
    4. LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor. Gong X, et al. PLoS One, 2012. PMID 22615920, Free PMC Article
    5. Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. Friedman MS, et al. J Biol Chem, 2009 May 22. PMID 19213727, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The endogenously expressed Lgr4 may act as an antagonist molecule that helps to fine-tune the R-spondin/norrin-mediated Lgr4-Wnt signaling during gonadal development.
      Title: A naturally occurring Lgr4 splice variant encodes a soluble antagonist useful for demonstrating the gonadal roles of Lgr4 in mammals.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables BMP receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within bone mineralization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic hindlimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lung growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within trachea cartilage morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    R-spondin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130575.1 → NP_001124047.1  R-spondin-2 precursor

      See identical proteins and their annotated locations for NP_001124047.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HRA2, D3ZCB0
      Related
      ENSRNOP00000062362.1, ENSRNOT00000067333.3
      Conserved Domains (2) summary
      cd00064
      Location:99 → 142
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam15913
      Location:40 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      75987217..76123984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595050.3 → XP_017450539.1  R-spondin-2 isoform X2

    2. XM_039079750.2 → XP_038935678.1  R-spondin-2 isoform X1

      UniProtKB/TrEMBL
      I7GAZ6
      Conserved Domains (2) summary
      pfam15913
      Location:47 → 148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:152 → 205
      TSP1_spondin; Spondin-like TSP1 domain

    3. XM_039079749.2 → XP_038935677.1  R-spondin-2 isoform X1

      UniProtKB/TrEMBL
      I7GAZ6
      Conserved Domains (2) summary
      pfam15913
      Location:47 → 148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:152 → 205
      TSP1_spondin; Spondin-like TSP1 domain

    4. XM_008765454.4 → XP_008763676.2  R-spondin-2 isoform X1

      UniProtKB/TrEMBL
      I7GAZ6
      Related
      ENSRNOP00000069239.1, ENSRNOT00000082741.3
      Conserved Domains (2) summary
      pfam15913
      Location:47 → 148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:152 → 205
      TSP1_spondin; Spondin-like TSP1 domain

    5. XM_063264114.1 → XP_063120184.1  R-spondin-2 isoform X3

      UniProtKB/TrEMBL
      A6HRA0

    6. XM_008765455.4 → XP_008763677.1  R-spondin-2 isoform X3

      See identical proteins and their annotated locations for XP_008763677.1

      UniProtKB/TrEMBL
      A6HRA0
      Conserved Domains (2) summary
      cd00064
      Location:99 → 142
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam15913
      Location:40 → 144
      Furin-like_2; Furin-like repeat, cysteine-rich
    Nucleotide Protein Strain
    Heading Accession and Version

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