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    Slc16a11 solute carrier family 16, member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc16a11provided by RGD
    Official Full Name
    solute carrier family 16, member 11provided by RGD
    Primary source
    RGD:1311125
    See related
    EnsemblRapid:ENSRNOG00000018748 AllianceGenome:RGD:1311125
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pyruvate transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport and lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Orthologous to human SLC16A11 (solute carrier family 16 member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 116.7), Lung (RPKM 61.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc16a11 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55427773..55431678)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54929129..54933021)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56822697..56826480)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene asialoglycoprotein receptor 2 Neighboring gene C-type lectin domain containing 10A Neighboring gene solute carrier family 16, member 13 Neighboring gene uncharacterized LOC120095129 Neighboring gene BCL6B, transcription repressor Neighboring gene microRNA 497

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms. Rusu V, et al. Cell, 2017 Jun 29. PMID 28666119, Free PMC Article
    2. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. SIGMA Type 2 Diabetes Consortium, et al. Nature, 2014 Feb 6. PMID 24390345, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC189362

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 11
    Names
    monocarboxylic acid transporters
    solute carrier family 16 (monocarboxylic acid transporters), member 11
    solute carrier family 16, member 11 (monocarboxylic acid transporter 11)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105797.2 → NP_001099267.2  monocarboxylate transporter 11

      See identical proteins and their annotated locations for NP_001099267.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A6G3
      Conserved Domains (2) summary
      cd06174
      Location:34 → 403
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:1 → 402
      2A0113; monocarboxylate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55427773..55431678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268651.1 → XP_063124721.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3

    2. XM_063268652.1 → XP_063124722.1  monocarboxylate transporter 11 isoform X7

    3. XM_063268653.1 → XP_063124723.1  monocarboxylate transporter 11 isoform X9

    4. XM_039085469.2 → XP_038941397.1  monocarboxylate transporter 11 isoform X6

      Conserved Domains (2) summary
      PHA03378
      Location:42 → 158
      PHA03378; EBNA-3B; Provisional
      cl28910
      Location:160 → 352
      MFS; Major Facilitator Superfamily

    5. XM_039085470.2 → XP_038941398.1  monocarboxylate transporter 11 isoform X8

      Conserved Domains (2) summary
      PHA03378
      Location:42 → 158
      PHA03378; EBNA-3B; Provisional
      cl28910
      Location:160 → 294
      MFS; Major Facilitator Superfamily

    6. XM_006246646.4 → XP_006246708.1  monocarboxylate transporter 11 isoform X2

      See identical proteins and their annotated locations for XP_006246708.1

      UniProtKB/TrEMBL
      A0A8I6ARJ5, B5DFC0, F7EKC7
      Related
      ENSRNOP00000025372.7, ENSRNOT00000025372.9
      Conserved Domains (2) summary
      cd06174
      Location:162 → 531
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:128 → 530
      2A0113; monocarboxylate transporter 1

    7. XM_039085468.2 → XP_038941396.1  monocarboxylate transporter 11 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:70 → 459
      MFS; Major Facilitator Superfamily

    8. XM_063268649.1 → XP_063124719.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3

    9. XM_039085465.2 → XP_038941393.1  monocarboxylate transporter 11 isoform X1

      Conserved Domains (2) summary
      PHA03378
      Location:42 → 158
      PHA03378; EBNA-3B; Provisional
      cd17423
      Location:160 → 549
      MFS_MCT11_13; Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters

    10. XM_039085466.2 → XP_038941394.1  monocarboxylate transporter 11 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:71 → 460
      MFS; Major Facilitator Superfamily

    11. XM_063268646.1 → XP_063124716.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3

    12. XM_006246649.4 → XP_006246711.1  monocarboxylate transporter 11 isoform X5

      See identical proteins and their annotated locations for XP_006246711.1

      UniProtKB/TrEMBL
      D4A6G3
      Conserved Domains (2) summary
      cd06174
      Location:34 → 403
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:1 → 402
      2A0113; monocarboxylate transporter 1

    13. XM_063268647.1 → XP_063124717.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3
      Related
      ENSRNOP00000061444.4, ENSRNOT00000067128.5

    14. XM_063268650.1 → XP_063124720.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3

    15. XM_063268648.1 → XP_063124718.1  monocarboxylate transporter 11 isoform X5

      UniProtKB/TrEMBL
      D4A6G3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001114973.1: Suppressed sequence

      Description
      NM_001114973.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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