Neil3 nei-like DNA glycosylase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Neil3provided by RGD
Official Full Name: nei-like DNA glycosylase 3provided by RGD
Primary source: RGD:1310562
See related: EnsemblRapid:ENSRNOG00000011688 AllianceGenome:RGD:1310562
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310562
Summary: Predicted to enable DNA binding activity and catalytic activity, acting on DNA. Predicted to be involved in base-excision repair and single strand break repair. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human NEIL3 (nei like DNA glycosylase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 24.7), Spleen (RPKM 5.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (45091401..45151419)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (38359305..38418528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (41079444..41138505)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that DNA glycosylases OGG1 and NEIL3 play multiple roles in governing essential neural stem cell characteristics.
Title: The DNA glycosylases OGG1 and NEIL3 influence differentiation potential, proliferation, and senescence-associated signs in neural stem cells.

Submit: New GeneRIF Correction

General gene information

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Markers

AU047451 (e-PCR)
- UniSTS:110496

Neil3 (e-PCR), detects polymorphism
- UniSTS:525732

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA N-glycosylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA N-glycosylase activity	ISO Inferred from Sequence Orthology more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	ISO Inferred from Sequence Orthology more info
enables bubble DNA binding	ISO Inferred from Sequence Orthology more info
enables class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	ISO Inferred from Sequence Orthology more info
involved_in single strand break repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endonuclease 8-like 3

Names: endonuclease VIII-like 3; nei endonuclease VIII-like 3; nei like 3

NP_001163817.1

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170346.1 → NP_001163817.1 endonuclease 8-like 3

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

D3ZKJ8

Related

ENSRNOP00000015623.7, ENSRNOT00000015623.8

Conserved Domains (5) summary

cd08969
Location:1 → 152

MeNeil3_N; N-terminal domain of metazoan Nei-like glycosylase 3 (NEIL3)

sd00029
Location:322 → 341

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:318 → 346

zf-RanBP; Zn-finger in Ran binding protein and others

pfam06831
Location:153 → 228

H2TH; Formamidopyrimidine-DNA glycosylase H2TH domain

pfam06839
Location:506 → 551

zf-GRF; GRF zinc finger