Lbr lamin B receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lbrprovided by RGD
Official Full Name: lamin B receptorprovided by RGD
Primary source: RGD:620813
See related: EnsemblRapid:ENSRNOG00000052574 AllianceGenome:RGD:620813
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C14SR; Nbp60
Summary: Enables nuclear localization sequence binding activity and protein-folding chaperone binding activity. Predicted to be involved in cholesterol biosynthetic process; neutrophil differentiation; and random inactivation of X chromosome. Located in nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 904.1), Spleen (RPKM 620.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q26

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (96071058..96095709, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (93539386..93564026, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (100431390..100450209, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BEMAD was used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on Lbr.
Title: Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	IEA Inferred from Electronic Annotation more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin-protein adaptor activity	IEA Inferred from Electronic Annotation more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables chromo shadow domain binding	IEA Inferred from Electronic Annotation more info
enables chromo shadow domain binding	ISO Inferred from Sequence Orthology more info
enables delta14-sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta14-sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables delta14-sterol reductase activity	ISO Inferred from Sequence Orthology more info
enables delta14-sterol reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear localization sequence binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in neutrophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in random inactivation of X chromosome	IEA Inferred from Electronic Annotation more info
involved_in random inactivation of X chromosome	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear lamina	IEA Inferred from Electronic Annotation more info
is_active_in nuclear lamina	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: delta(14)-sterol reductase LBR

Names: 3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; delta-14-SR; integral nuclear envelope inner membrane protein; sterol C14-reductase

NP_001380594.1

EC 1.3.1.70

XP_038947059.1

EC 1.3.1.70

XP_038947060.1

EC 1.3.1.70

XP_038947061.1

EC 1.3.1.70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393665.1 → NP_001380594.1 delta(14)-sterol reductase LBR

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6AEP6, A6JGK3

Related

ENSRNOP00000090637.2, ENSRNOT00000095219.2

Conserved Domains (2) summary

pfam09465
Location:1 → 55

LBR_tudor; Lamin-B receptor of TUDOR domain

cl21511
Location:213 → 621

PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

96071058..96095709 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091132.2 → XP_038947060.1 delta(14)-sterol reductase LBR isoform X1

UniProtKB/TrEMBL

A0A8I6AEP6, A6JGK3

Conserved Domains (2) summary

pfam09465
Location:1 → 55

LBR_tudor; Lamin-B receptor of TUDOR domain

cl21511
Location:213 → 621

PEMT; Phospholipid methyltransferase
XM_039091131.2 → XP_038947059.1 delta(14)-sterol reductase LBR isoform X1

UniProtKB/TrEMBL

A0A8I6AEP6, A6JGK3

Conserved Domains (2) summary

pfam09465
Location:1 → 55

LBR_tudor; Lamin-B receptor of TUDOR domain

cl21511
Location:213 → 621

PEMT; Phospholipid methyltransferase
XM_039091133.2 → XP_038947061.1 delta(14)-sterol reductase LBR isoform X1

UniProtKB/TrEMBL

A0A8I6AEP6, A6JGK3

Conserved Domains (2) summary

pfam09465
Location:1 → 55

LBR_tudor; Lamin-B receptor of TUDOR domain

cl21511
Location:213 → 621

PEMT; Phospholipid methyltransferase