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    Sik3 SIK family kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684112, updated on 27-Dec-2024

    Summary

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    Symbol
    Sik3provided by RGD
    Full Name
    SIK family kinase 3provided by RGD
    Primary source
    RGD:1593938
    See related
    EnsemblRapid:ENSRNOG00000045931 AllianceGenome:RGD:1593938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and tau-protein kinase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of TOR signaling; and protein phosphorylation. Predicted to act upstream of or within endochondral bone morphogenesis; limb morphogenesis; and regulation of protein localization. Predicted to be active in cytoplasm. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 87.4), Kidney (RPKM 73.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sik3 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55208969..55419138)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46312253..46522444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50310263..50520284)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 Neighboring gene ribosomal protein S26, pseudogene 6 Neighboring gene uncharacterized LOC120094333 Neighboring gene POU class 5 homeobox 1, pseudogene 1 Neighboring gene apolipoprotein A1 Neighboring gene apolipoprotein C3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling. Cai Y, et al. Arterioscler Thromb Vasc Biol, 2021 Sep. PMID 34196217, Free PMC Article
    2. The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling. Csukasi F, et al. Sci Transl Med, 2018 Sep 19. PMID 30232230, Free PMC Article
    3. cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes. Berggreen C, et al. Cell Signal, 2012 Sep. PMID 22588126
    4. SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Sasagawa S, et al. Development, 2012 Mar. PMID 22318228
    5. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. Lizcano JM, et al. EMBO J, 2004 Feb 25. PMID 14976552, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling.
      Title: Salt-Inducible Kinase 3 Promotes Vascular Smooth Muscle Cell Proliferation and Arterial Restenosis by Regulating AKT and PKA-CREB Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endochondral ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within limb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC2 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase SIK3
    NP_001258145.2
    XP_017451401.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271216.2 → NP_001258145.2  serine/threonine-protein kinase SIK3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      M0RD40
      Related
      ENSRNOP00000067534.3, ENSRNOT00000073507.4
      Conserved Domains (2) summary
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
      cl21463
      Location:346 → 390
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55208969..55419138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595912.3 → XP_017451401.1  serine/threonine-protein kinase SIK3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0T3
      Related
      ENSRNOP00000084757.1, ENSRNOT00000098139.2
      Conserved Domains (3) summary
      smart00220
      Location:66 → 317
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14071
      Location:65 → 317
      STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
      cl21463
      Location:346 → 390
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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