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    Gcn1 GCN1 activator of EIF2AK4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690632, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gcn1provided by RGD
    Official Full Name
    GCN1 activator of EIF2AK4provided by RGD
    Primary source
    RGD:1593434
    See related
    EnsemblRapid:ENSRNOG00000021871 AllianceGenome:RGD:1593434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gcn1l1
    Summary
    Predicted to enable several functions, including protein serine/threonine kinase activator activity; stalled ribosome sensor activity; and ubiquitin-protein transferase regulator activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and protein-RNA covalent cross-linking repair. Predicted to be active in cytosolic ribosome. Orthologous to human GCN1 (GCN1 activator of EIF2AK4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 174.2), Adrenal (RPKM 162.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gcn1 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46652273..46715119, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (40991512..41052661, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46728684..46789696, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene BICD family like cargo adaptor 1 Neighboring gene RAB35, member RAS oncogene family Neighboring gene uncharacterized LOC120096002 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene paxillin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. Roffé M, et al. J Biol Chem, 2013 Apr 12. PMID 23447528, Free PMC Article
    2. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Cambiaghi TD, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333428
    3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
    4. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables stalled ribosome sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-RNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    stalled ribosome sensor GCN1
    Names
    GCN1 eIF2 alpha kinase activator-like 1
    GCN1 general control of amino-acid synthesis 1-like 1
    GCN1, eIF2 alpha kinase activator homolog
    eIF-2-alpha kinase activator GCN1
    translational activator GCN1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168664.1 → NP_001162135.1  stalled ribosome sensor GCN1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6G9H9, F1LRI5
      Related
      ENSRNOP00000001517.7, ENSRNOT00000001517.9
      Conserved Domains (4) summary
      cd00020
      Location:1498 → 1601
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam12074
      Location:355 → 705
      DUF3554; Domain of unknown function (DUF3554)
      pfam13646
      Location:1616 → 1721
      HEAT_2; HEAT repeats
      sd00044
      Location:1461 → 1485
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      46652273..46715119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089791.2 → XP_038945719.1  stalled ribosome sensor GCN1 isoform X2

      Conserved Domains (1) summary
      sd00044
      Location:1215 → 1249
      HEAT; HEAT repeat [structural motif]

    2. XM_039089790.2 → XP_038945718.1  stalled ribosome sensor GCN1 isoform X1

      Conserved Domains (1) summary
      sd00044
      Location:1215 → 1249
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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