Gli1 GLI family zinc finger 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gli1provided by RGD
Official Full Name: GLI family zinc finger 1provided by RGD
Primary source: RGD:621673
See related: EnsemblRapid:ENSRNOG00000025120 AllianceGenome:RGD:621673
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gli
Summary: Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in liver regeneration; prostate gland development; and spermatid development. Predicted to be located in axoneme; cytosol; and nucleoplasm. Predicted to be part of GLI-SUFU complex. Predicted to be active in cytoplasm and nucleus. Biomarker of ocular hypertension and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in gallbladder cancer and preaxial polydactyly I. Orthologous to human GLI1 (GLI family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 36.2), Lung (RPKM 17.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65042237..65054888, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63156926..63169579, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70620794..70633171, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in obese rats with non-alcoholic fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes.
Title: Enhancement of biochemical and genomic pathways through lycopene-loaded nano-liposomes: Alleviating insulin resistance, hepatic steatosis, and autophagy in obese rats with non-alcoholic fatty liver disease: Involvement of SMO, GLI-1, and PTCH-1 genes.
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Title: Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.
Title: Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.
GLI1 enhanced apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) expression by binding with its promoter
Title: GLI1-mediated pulmonary artery smooth muscle cell pyroptosis contributes to hypoxia-induced pulmonary hypertension.
Dhh and Gli1 might function in concert to regenerate adrenocortical autografts.
Title: Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats.
Study provide evidence that spatiotemporal expression of Shh, Ptch1, and Gli1 was imbalanced during development of the lumbosacral spinal cord in rat embryos with ethylenethiourea induced anorectal malformations (ARMs). This imbalance may contribute to maldevelopment of the lumbosacral spinal cord and provide a molecular explanation for the complications observed in patients with ARMs.
Title: The Expression of Shh, Ptch1, and Gli1 in the Developing Caudal Spinal Cord of Fetal Rats With Anorectal Malformations.
The results suggest that SHH-Gli pathway is involved in the pathogenesis of Rheumatoid arthritis, and blocking SHH-Gli pathway inhibits Rheumatoid arthritis-synovial fibroblast cell proliferation and increases cell apoptosis, which may shed light on developing new ideas for Rheumatoid arthritis treatment.
Title: The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis.
This study characterizes, for the first time, the transcriptional response of cardiomyocytes to Shh and establishes a critical role for Smo coupling to Gi in Hh signaling in the normal and ischemic myocardium
Title: Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium.
The expression of Shh, Smo and Gli1 at the protein and mRNA level in hepatocytes of rats with chronic fluorosis can be increased by fluoride and may be inhibited by cyclopamine.
Title: Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis.
The present results suggested that inhibition of Shh signaling pathway exacerbated rat ischemic damage caused by pMCAO, which may be correlated with down-regulated expression of Gli1, Ptch1 and SOD1.
Title: Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

AU043488 (e-PCR)
- UniSTS:160050

UniSTS:465478 (e-PCR)
- UniSTS:465478

Gli1 (e-PCR), detects polymorphism
- UniSTS:465478

UniSTS:259693 (e-PCR)
- UniSTS:259693

Gli1 (e-PCR), detects polymorphism
- UniSTS:259693

RH130356 (e-PCR)
- UniSTS:213640

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebellar cortex morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
involved_in epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within liver regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within notochord regression	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pituitary gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventral midline development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of GLI-SUFU complex	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein GLI1

Names: GLI-Kruppel family member GLI1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191910.1 → NP_001178839.1 zinc finger protein GLI1

See identical proteins and their annotated locations for NP_001178839.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HQV2, G3V6X8

Conserved Domains (4) summary

COG5236
Location:196 → 433

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:303 → 325

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 344

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:237 → 265

FOXP-CC; FOXP coiled-coil domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

65042237..65054888 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241443.5 → XP_006241505.1 zinc finger protein GLI1 isoform X1

See identical proteins and their annotated locations for XP_006241505.1

UniProtKB/TrEMBL

A6HQV2, G3V6X8

Conserved Domains (4) summary

COG5236
Location:196 → 433

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:303 → 325

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 344

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:237 → 265

FOXP-CC; FOXP coiled-coil domain
XM_008765375.4 → XP_008763597.1 zinc finger protein GLI1 isoform X1

See identical proteins and their annotated locations for XP_008763597.1

UniProtKB/TrEMBL

A6HQV2, G3V6X8

Conserved Domains (4) summary

COG5236
Location:196 → 433

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:303 → 325

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 344

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:237 → 265

FOXP-CC; FOXP coiled-coil domain
XM_006241442.5 → XP_006241504.1 zinc finger protein GLI1 isoform X1

See identical proteins and their annotated locations for XP_006241504.1

UniProtKB/TrEMBL

A6HQV2, G3V6X8

Related

ENSRNOP00000009803.5, ENSRNOT00000009803.9

Conserved Domains (4) summary

COG5236
Location:196 → 433

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:303 → 325

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 344

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:237 → 265

FOXP-CC; FOXP coiled-coil domain
XM_017594631.3 → XP_017450120.1 zinc finger protein GLI1 isoform X1

UniProtKB/TrEMBL

A6HQV2, G3V6X8

Conserved Domains (4) summary

COG5236
Location:196 → 433

COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

sd00017
Location:303 → 325

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:317 → 344

zf-H2C2_2; Zinc-finger double domain

pfam16159
Location:237 → 265

FOXP-CC; FOXP coiled-coil domain