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    Ankrd53 ankyrin repeat domain 53 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500230, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ankrd53provided by RGD
    Official Full Name
    ankyrin repeat domain 53provided by RGD
    Primary source
    RGD:1561200
    See related
    EnsemblRapid:ENSRNOG00000021402 AllianceGenome:RGD:1561200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561200
    Summary
    Predicted to be involved in mitotic metaphase chromosome alignment; regulation of microtubule cytoskeleton organization; and regulation of mitotic cytokinesis. Predicted to be located in spindle. Predicted to be active in spindle pole. Orthologous to human ANKRD53 (ankyrin repeat domain 53). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Testes (RPKM 71.7), Heart (RPKM 61.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd53 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117804702..117810650)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116245561..116253018)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115439325..115447995)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ventral anterior homeobox 2 Neighboring gene uncharacterized LOC108350721 Neighboring gene ATPase H+ transporting V1 subunit B1 Neighboring gene uncharacterized LOC134486595 Neighboring gene testis expressed 261 Neighboring gene 60S ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ANKRD53 interacts with DDA3 and regulates chromosome integrity during mitosis. Kim S, et al. Biochem Biophys Res Commun, 2016 Feb 12. PMID 26820536
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitotic metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain 53; ankyrin repeat domain-containing protein 53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431826.1 → NP_001418755.1  ankyrin repeat domain 53

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAP4

    2. NM_001431827.1 → NP_001418756.1  ankyrin repeat domain 53

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAP4

    3. NM_001431828.1 → NP_001418757.1  ankyrin repeat domain 53

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAP4

    4. NM_001431829.1 → NP_001418758.1  ankyrin repeat domain 53

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IAP4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117804702..117810650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_056985480.2 → XP_056841460.2  ankyrin repeat domain-containing protein 53

      UniProtKB/TrEMBL
      F1M9S7
      Related
      ENSRNOP00000033393.4, ENSRNOT00000033234.7
    Nucleotide Protein Strain
    Heading Accession and Version

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    Research Materials