Ppp1r7 protein phosphatase 1, regulatory subunit 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp1r7provided by RGD
Official Full Name: protein phosphatase 1, regulatory subunit 7provided by RGD
Primary source: RGD:1308169
See related: EnsemblRapid:ENSRNOG00000016974 AllianceGenome:RGD:1308169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sds22
Summary: Predicted to enable protein phosphatase regulator activity. Predicted to act upstream of or within chromosome segregation. Predicted to be located in chromosome. Orthologous to human PPP1R7 (protein phosphatase 1 regulatory subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 141.9), Thymus (RPKM 82.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (101333472..101358589)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (93886068..93911198)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (99556587..100504077)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 are found in rat liver nuclei
Title: Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei.
conserved portion of Sds22 folds into a curved superhelix; demonstrate that mutation to alanine of any of eight residues at the concave surface of this superhelix thwarts the interaction with PP1 [Sds22]
Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome segregation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase 1 regulatory subunit 7

Names: protein phosphatase 1 regulatory subunit 22; protein phosphatase 1, regulatory (inhibitor) subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009825.2 → NP_001009825.1 protein phosphatase 1 regulatory subunit 7

See identical proteins and their annotated locations for NP_001009825.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q5HZV9

UniProtKB/TrEMBL

A0A8I6AM99, A6JQY6

Related

ENSRNOP00000081944.1, ENSRNOT00000095497.2

Conserved Domains (3) summary

sd00033
Location:100 → 121

LRR_RI; leucine-rich repeat [structural motif]

NF033189
Location:68 → 260

internalin_A; class 1 internalin InlA

cd21340
Location:169 → 354

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

101333472..101358589

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767362.4 → XP_008765584.1 protein phosphatase 1 regulatory subunit 7 isoform X1

Conserved Domains (2) summary

sd00033
Location:100 → 121

LRR_RI; leucine-rich repeat [structural motif]

cd21340
Location:97 → 272

PPP1R42; protein phosphatase 1 regulatory subunit 42