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    Ube2u ubiquitin conjugating enzyme E2 U [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500511, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ube2uprovided by RGD
    Official Full Name
    ubiquitin conjugating enzyme E2 Uprovided by RGD
    Primary source
    RGD:1565480
    See related
    EnsemblRapid:ENSRNOG00000023895 AllianceGenome:RGD:1565480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565480
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein polyubiquitination. Predicted to be part of HULC complex. Orthologous to human UBE2U (ubiquitin conjugating enzyme E2 U). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 80.7), Adrenal (RPKM 37.4) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2u in Genome Data Viewer
    Location:
    5q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (120233749..120301514)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (115118234..115187296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (118574647..118642810)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene U6 spliceosomal RNA Neighboring gene RNA, U6 small nuclear 233 Neighboring gene cache domain containing 1 Neighboring gene uncharacterized LOC134479016

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of HULC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin conjugating enzyme E2 U; ubiquitin-conjugating enzyme E2 U
    Names
    ubiquitin-conjugating enzyme E2U (putative)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431215.1 → NP_001418144.1  ubiquitin conjugating enzyme E2 U isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1M158

    2. NM_001431216.1 → NP_001418145.1  ubiquitin conjugating enzyme E2 U isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    3. NM_001431217.1 → NP_001418146.1  ubiquitin conjugating enzyme E2 U isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NM_001431218.1 → NP_001418147.1  ubiquitin conjugating enzyme E2 U isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001431219.1 → NP_001418148.1  ubiquitin conjugating enzyme E2 U isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      120233749..120301514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238443.5 → XP_006238505.1  ubiquitin-conjugating enzyme E2 U isoform X1

      Related
      ENSRNOP00000028997.6, ENSRNOT00000035949.9
      Conserved Domains (2) summary
      COG5078
      Location:13 → 156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:16 → 156
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. XM_039111114.2 → XP_038967042.1  ubiquitin-conjugating enzyme E2 U isoform X2

      Conserved Domains (1) summary
      cd00195
      Location:3 → 113
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. XM_063261314.1 → XP_063117384.1  ubiquitin-conjugating enzyme E2 U isoform X3

    4. XM_039111116.2 → XP_038967044.1  ubiquitin-conjugating enzyme E2 U isoform X4

    5. XM_039111115.2 → XP_038967043.1  ubiquitin-conjugating enzyme E2 U isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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