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    Glrx5 glutaredoxin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362776, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Glrx5provided by RGD
    Official Full Name
    glutaredoxin 5provided by RGD
    Primary source
    RGD:1308383
    See related
    EnsemblRapid:ENSRNOG00000004206 AllianceGenome:RGD:1308383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308383
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in [2Fe-2S] cluster assembly; protein maturation by [2Fe-2S] cluster transfer; and protein maturation by [4Fe-4S] cluster transfer. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 3. Orthologous to human GLRX5 (glutaredoxin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 295.3), Heart (RPKM 287.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glrx5 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (129752902..129763278)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (123988461..123998545)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (128750503..128760880)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103610 Neighboring gene ribosomal protein L6, pseudogene 1 Neighboring gene uncharacterized LOC134479255 Neighboring gene uncharacterized LOC100912332 Neighboring gene small Cajal body-specific RNA 13 Neighboring gene uncharacterized LOC134479469 Neighboring gene Tcl1 family Akt coactivator A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. Ye H, et al. J Clin Invest, 2010 May. PMID 20364084, Free PMC Article
    2. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Baker PR 2nd, et al. Brain, 2014 Feb. PMID 24334290, Free PMC Article
    3. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, et al. Biochim Biophys Acta, 2011 Jan. PMID 20620191
    4. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein maturation by [2Fe-2S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of iron-sulfur cluster assembly complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutaredoxin-related protein 5, mitochondrial
    Names
    glutaredoxin 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108722.2 → NP_001102192.1  glutaredoxin-related protein 5, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001102192.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JES1
      Conserved Domains (1) summary
      cd03028
      Location:41 → 131
      GRX_PICOT_like; Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain ...

    2. NM_001429150.1 → NP_001416079.1  glutaredoxin-related protein 5, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      129752902..129763278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262127.1 → XP_063118197.1  glutaredoxin-related protein 5, mitochondrial isoform X1

      Related
      ENSRNOP00000005781.5, ENSRNOT00000005781.7
    Nucleotide Protein Strain
    Heading Accession and Version

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