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    Gas2l1 growth arrest-specific 2 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360973, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gas2l1provided by RGD
    Official Full Name
    growth arrest-specific 2 like 1provided by RGD
    Primary source
    RGD:1311206
    See related
    EnsemblRapid:ENSRNOG00000009040 AllianceGenome:RGD:1311206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity; cytoskeletal anchor activity; and microtubule binding activity. Predicted to be involved in several processes, including cytoskeleton organization; negative regulation of microtubule depolymerization; and protein localization to microtubule plus-end. Predicted to be located in actin filament and microtubule. Predicted to be active in cytoplasm. Predicted to colocalize with microtubule plus-end and stress fiber. Orthologous to human GAS2L1 (growth arrest specific 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 45.1), Kidney (RPKM 44.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gas2l1 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (84169398..84175514, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (79955350..79961830, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (85308443..85318475, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene small nucleolar RNA, C/D box 125 Neighboring gene uncharacterized LOC120096647 Neighboring gene RAS-like, family 10, member A Neighboring gene EWS RNA-binding protein 1 Neighboring gene rhomboid domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization. van de Willige D, et al. EMBO Rep, 2019 Nov 5. PMID 31486213, Free PMC Article
    2. Protein products of human Gas2-related genes on chromosomes 17 and 22 (hGAR17 and hGAR22) associate with both microfilaments and microtubules. Goriounov D, et al. J Cell Sci, 2003 Mar 15. PMID 12584248
    3. GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins. Stroud MJ, et al. J Cell Sci, 2014 Jun 15. PMID 24706950, Free PMC Article
    4. GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells. Gamper I, et al. Exp Hematol, 2009 May. PMID 19375645
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal anchor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal anchor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule bundle formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GAS2-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401406.1 → NP_001388335.1  GAS2-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IKK5, D3ZR69
      Related
      ENSRNOP00000075569.3, ENSRNOT00000080541.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      84169398..84175514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092216.2 → XP_038948144.1  GAS2-like protein 1 isoform X1

      Conserved Domains (1) summary
      PHA03247
      Location:3 → 220
      PHA03247; large tegument protein UL36; Provisional

    2. XM_063273391.1 → XP_063129461.1  GAS2-like protein 1 isoform X3

    3. XM_039092217.2 → XP_038948145.1  GAS2-like protein 1 isoform X2

      Conserved Domains (2) summary
      pfam02187
      Location:208 → 276
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cd21268
      Location:18 → 152
      CH_GAS2L1_2; calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108365.1: Suppressed sequence

      Description
      NM_001108365.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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