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    Pknox1 PBX/knotted 1 homeobox 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294322, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pknox1provided by RGD
    Official Full Name
    PBX/knotted 1 homeobox 1provided by RGD
    Primary source
    RGD:1305003
    See related
    EnsemblRapid:ENSRNOG00000001184 AllianceGenome:RGD:1305003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in angiogenesis. Predicted to act upstream of or within camera-type eye development; hemopoiesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of transcription regulator complex. Orthologous to human PKNOX1 (PBX/knotted 1 homeobox 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 73.5), Thymus (RPKM 71.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pknox1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (9664120..9706328)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (9662866..9705030)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (10331608..10358922)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit V3 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene cystathionine beta synthase Neighboring gene U2 small nuclear RNA auxiliary factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Penkov D, et al. Mol Cell Biol, 2005 Dec. PMID 16314502, Free PMC Article
    2. MiR-17 family-mediated regulation of Pknox1 influences hepatic steatosis and insulin signaling. Ye D, et al. J Cell Mol Med, 2018 Dec. PMID 30338914, Free PMC Article
    3. The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem and progenitor cell activity. Di Rosa P, et al. Dev Biol, 2007 Nov 15. PMID 17904118
    4. In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis. Yoshioka H, et al. Mol Cell Biol, 2007 Nov. PMID 17875925, Free PMC Article
    5. Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. Bailey JS, et al. Mol Endocrinol, 2004 May. PMID 14764653, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC109503

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein PKNOX1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013074.3 → NP_001013092.1  homeobox protein PKNOX1 isoform 1

      See identical proteins and their annotated locations for NP_001013092.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. NM_001434615.1 → NP_001421544.1  homeobox protein PKNOX1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AIY1

    3. NM_001434616.1 → NP_001421545.1  homeobox protein PKNOX1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      9664120..9706328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098545.2 → XP_038954473.1  homeobox protein PKNOX1 isoform X1

      Related
      ENSRNOP00000001566.7, ENSRNOT00000001566.8
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    2. XM_063279041.1 → XP_063135111.1  homeobox protein PKNOX1 isoform X2

    3. XM_039098547.2 → XP_038954475.1  homeobox protein PKNOX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    4. XM_039098544.2 → XP_038954472.1  homeobox protein PKNOX1 isoform X1

      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    5. XM_039098546.2 → XP_038954474.1  homeobox protein PKNOX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Related
      ENSRNOP00000079378.1, ENSRNOT00000107714.2
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    6. XM_039098548.2 → XP_038954476.1  homeobox protein PKNOX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    7. XM_039098549.2 → XP_038954477.1  homeobox protein PKNOX1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    8. XM_008772808.4 → XP_008771030.1  homeobox protein PKNOX1 isoform X1

      See identical proteins and their annotated locations for XP_008771030.1

      UniProtKB/TrEMBL
      A0A8I6AIY1, A0A8I6G373, Q5BJP1
      Conserved Domains (2) summary
      pfam05920
      Location:277 → 316
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:80 → 165
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    Nucleotide Protein Strain
    Heading Accession and Version

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