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    Ism2 isthmin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 681936, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ism2provided by RGD
    Official Full Name
    isthmin 2provided by RGD
    Primary source
    RGD:1589343
    See related
    EnsemblRapid:ENSRNOG00000050312 AllianceGenome:RGD:1589343
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in extracellular region. Orthologous to human ISM2 (isthmin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 23.3), Brain (RPKM 7.7) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ism2 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (112652772..112675098, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (106921213..106944291, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111309054..111329967, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479236 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene activator of Hsp90 ATPase activity 1 Neighboring gene uncharacterized LOC134479239 Neighboring gene serine palmitoyltransferase, long chain base subunit 2 Neighboring gene uncharacterized LOC134479238 Neighboring gene uncharacterized LOC120103582

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    isthmin 2; isthmin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432128.1 → NP_001419057.1  isthmin 2 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      M0RD17

    2. NM_001432129.1 → NP_001419058.1  isthmin 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001432132.1 → NP_001419061.1  isthmin 2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A9X1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      112652772..112675098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262685.1 → XP_063118755.1  isthmin-2 isoform X3

    2. XM_063262684.1 → XP_063118754.1  isthmin-2 isoform X2

    3. XM_008764895.4 → XP_008763117.1  isthmin-2 isoform X1

      Related
      ENSRNOP00000090028.2, ENSRNOT00000106430.2
      Conserved Domains (1) summary
      cl02758
      Location:316 → 476
      AMOP; AMOP domain

    RNA

    1. XR_010052295.1 RNA Sequence

    2. XR_010052293.1 RNA Sequence

    3. XR_005506125.2 RNA Sequence

    4. XR_010052294.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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