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    Akr1c13 aldo-keto reductase family 1, member C13 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361266, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Akr1c13provided by RGD
    Official Full Name
    aldo-keto reductase family 1, member C13provided by RGD
    Primary source
    RGD:1308232
    See related
    EnsemblRapid:ENSRNOG00000062679 AllianceGenome:RGD:1308232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Akr1c12; Akr1c12T
    Summary
    Predicted to enable bile acid binding activity; ketosteroid monooxygenase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 416.4), Kidney (RPKM 179.5) and 1 other tissue See more
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    Genomic context

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    See Akr1c13 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70874110..70907518)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65964186..65997598)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69614323..69647772)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member C12-like 1 Neighboring gene voltage-dependent anion channel 1, pseudogene 6 Neighboring gene uncharacterized LOC134482872 Neighboring gene aldo-keto reductase family 1, member C19 Neighboring gene aldo-keto reductase family 1, member C12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables androsterone dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ketosteroid monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in doxorubicin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in progesterone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aldo-keto reductase family 1, member C12
    Names
    aldo-keto reductase family 1, member C12 temp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170342.1 → NP_001163813.1  aldo-keto reductase family 1, member C12

      See identical proteins and their annotated locations for NP_001163813.1

      Status: VALIDATED

      Source sequence(s)
      CN542908, EX487988
      UniProtKB/TrEMBL
      D3ZPY8, Q2MHD9
      Related
      ENSRNOP00000037905.4, ENSRNOT00000029049.7
      Conserved Domains (2) summary
      COG0656
      Location:8 → 305
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      70874110..70907518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600632.3 → XP_017456121.1  aldo-keto reductase family 1, member C12 isoform X2

      UniProtKB/TrEMBL
      Q2MHD9
      Conserved Domains (1) summary
      cd19108
      Location:36 → 315
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    2. XM_006254190.5 → XP_006254252.1  aldo-keto reductase family 1, member C12 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AD50, Q2MHD9
      Related
      ENSRNOP00000089705.1, ENSRNOT00000102233.2
      Conserved Domains (2) summary
      COG0656
      Location:89 → 353
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:77 → 345
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    3. XM_006254191.2 → XP_006254253.1  aldo-keto reductase family 1, member C12 isoform X3

      See identical proteins and their annotated locations for XP_006254253.1

      UniProtKB/TrEMBL
      D3ZPY8, Q2MHD9
      Conserved Domains (2) summary
      COG0656
      Location:8 → 305
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    4. XM_008771874.3 → XP_008770096.1  aldo-keto reductase family 1, member C12 isoform X3

      See identical proteins and their annotated locations for XP_008770096.1

      UniProtKB/TrEMBL
      D3ZPY8, Q2MHD9
      Related
      ENSRNOP00000089272.2, ENSRNOT00000096532.2
      Conserved Domains (2) summary
      COG0656
      Location:8 → 305
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    5. XM_039095920.2 → XP_038951848.1  aldo-keto reductase family 1, member C12 isoform X4

      Conserved Domains (1) summary
      cl00470
      Location:1 → 230
      AKR_SF; Aldo-keto reductase (AKR) superfamily

    6. XM_008771873.3 → XP_008770095.1  aldo-keto reductase family 1, member C12 isoform X3

      See identical proteins and their annotated locations for XP_008770095.1

      UniProtKB/TrEMBL
      D3ZPY8, Q2MHD9
      Conserved Domains (2) summary
      COG0656
      Location:8 → 305
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:16 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version

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