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    Ak7 adenylate kinase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314416, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ak7provided by RGD
    Official Full Name
    adenylate kinase 7provided by RGD
    Primary source
    RGD:1309600
    See related
    EnsemblRapid:ENSRNOG00000055714 AllianceGenome:RGD:1309600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable (d)CMP kinase activity; adenylate kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside monophosphate phosphorylation. Predicted to act upstream of or within several processes, including axoneme assembly; epithelial cilium movement involved in extracellular fluid movement; and inflammatory response to antigenic stimulus. Predicted to be located in extracellular region. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in spermatogenic failure 27. Orthologous to human AK7 (adenylate kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 51.7), Lung (RPKM 31.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ak7 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (130376499..130444674)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (124611789..124679978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (129538648..129606960)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene autophagy related 2B Neighboring gene uncharacterized LOC134479256 Neighboring gene GSK3B interacting protein Neighboring gene poly (A) polymerase alpha Neighboring gene transfer RNA proline (anticodon AGG) 18 Neighboring gene uncharacterized LOC120103616

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Fernandez-Gonzalez A, et al. Am J Respir Cell Mol Biol, 2009 Mar. PMID 18776131, Free PMC Article
    2. The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. Panayiotou C, et al. Biochem J, 2011 Feb 1. PMID 21080915
    3. Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein. Van Rompay AR, et al. Eur J Biochem, 1999 Apr. PMID 10215863
    4. The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Amiri M, et al. Int J Biochem Cell Biol, 2013 May. PMID 23416111
    5. Congenital hydrocephalus in genetically engineered mice. Vogel P, et al. Vet Pathol, 2012 Jan. PMID 21746835

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (d)CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of localization in cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inflammatory response to antigenic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 7
    Names
    putative adenylate kinase 7
    NP_001101525.2
    XP_017449671.1
    XP_063118071.1
    XP_063118072.1
    XP_063118073.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108055.3 → NP_001101525.2  adenylate kinase 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K524
      Related
      ENSRNOP00000073263.2, ENSRNOT00000082522.3
      Conserved Domains (5) summary
      COG0451
      Location:149 → 299
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
      cd01428
      Location:371 → 549
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam05186
      Location:680 → 721
      Dpy-30; Dpy-30 motif
      cl21454
      Location:195 → 300
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl23720
      Location:615 → 693
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      130376499..130444674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594182.3 → XP_017449671.1  adenylate kinase 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K524
      Related
      ENSRNOP00000105834.1, ENSRNOT00000171648.1
      Conserved Domains (5) summary
      COG0451
      Location:149 → 299
      WcaG; Nucleoside-diphosphate-sugar epimerase [Cell wall/membrane/envelope biogenesis]
      cd01428
      Location:371 → 549
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      pfam05186
      Location:680 → 721
      Dpy-30; Dpy-30 motif
      cl21454
      Location:195 → 300
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl23720
      Location:615 → 693
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. XM_063262001.1 → XP_063118071.1  adenylate kinase 7 isoform X2

    3. XM_063262002.1 → XP_063118072.1  adenylate kinase 7 isoform X2

    4. XM_063262003.1 → XP_063118073.1  adenylate kinase 7 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ71, A6KBD4
      Related
      ENSRNOP00000070935.2, ENSRNOT00000083626.3
    Nucleotide Protein Strain
    Heading Accession and Version

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