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    Mfsd14a major facilitator superfamily domain containing 14A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 103689987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfsd14aprovided by RGD
    Official Full Name
    major facilitator superfamily domain containing 14Aprovided by RGD
    Primary source
    RGD:9294064
    See related
    EnsemblRapid:ENSRNOG00000086718 AllianceGenome:RGD:9294064
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hiat1
    Summary
    Predicted to enable pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in pyrimidine nucleotide-sugar transmembrane transport. Predicted to act upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in Golgi membrane. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 153.6), Brain (RPKM 152.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd14a in Genome Data Viewer
    Location:
    2q42
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (207264081..207305880, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204579174..204611600, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219661204..219697548, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene SAS-6 centriolar assembly protein Neighboring gene uncharacterized LOC102548510 Neighboring gene solute carrier family 35 member A3 Neighboring gene amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase Neighboring gene uncharacterized LOC120100926

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Doran J, et al. Reproduction, 2016 Jul. PMID 27107036
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC188651

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyrimidine nucleotide-sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatid nucleus differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hippocampus abundant transcript 1 protein
    Names
    hippocampus abundant transcript 1
    hippocampus abundant transcript-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329200.1 → NP_001316129.1  hippocampus abundant transcript 1 protein

      Status: PROVISIONAL

      Source sequence(s)
      BC160912
      UniProtKB/TrEMBL
      A0A0G2KB40, A6HVA5, B1H293, F7F1C3
      Related
      ENSRNOP00000020907.4, ENSRNOT00000020907.9
      Conserved Domains (1) summary
      cd17387
      Location:37 → 449
      MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      207264081..207305880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281103.1 → XP_063137173.1  hippocampus abundant transcript 1 protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB40

    2. XM_006233223.5 → XP_006233285.1  hippocampus abundant transcript 1 protein isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB40
      Related
      ENSRNOP00000075642.3, ENSRNOT00000088123.3
      Conserved Domains (2) summary
      cd06174
      Location:26 → 383
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:28 → 372
      MFS_1; Major Facilitator Superfamily

    3. XM_063281104.1 → XP_063137174.1  hippocampus abundant transcript 1 protein isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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