Eno4 enolase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eno4provided by RGD
Official Full Name: enolase 4provided by RGD
Primary source: RGD:1308333
See related: EnsemblRapid:ENSRNOG00000018310 AllianceGenome:RGD:1308333
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308333
Summary: Predicted to enable phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Predicted to act upstream of or within cilium organization and flagellated sperm motility. Predicted to be located in sperm principal piece. Predicted to be part of phosphopyruvate hydratase complex. Orthologous to human ENO4 (enolase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 24.2), Testes (RPKM 20.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (268073318..268113494)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (258096406..258119811)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (280097061..280129750)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables phosphopyruvate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphopyruvate hydratase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycolytic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of phosphopyruvate hydratase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: enolase 4

Names: enolase family member 4; enolase-like protein ENO4

NP_001127977.1

EC 4.2.1.11

XP_006231731.1

EC 4.2.1.11

XP_017444353.1

EC 4.2.1.11

XP_017444354.1

EC 4.2.1.11

XP_038959219.1

EC 4.2.1.11

XP_038959224.1

EC 4.2.1.11

XP_038959225.1

EC 4.2.1.11

XP_038959227.1

EC 4.2.1.11

XP_063138881.1

EC 4.2.1.11

XP_063138884.1

EC 4.2.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134505.1 → NP_001127977.1 enolase 4

See identical proteins and their annotated locations for NP_001127977.1

Status: PROVISIONAL

Source sequence(s)

CH473986

UniProtKB/TrEMBL

A6JI77

Related

ENSRNOP00000099518.1, ENSRNOT00000139597.1

Conserved Domains (2) summary

TIGR01060
Location:68 → 574

eno; phosphopyruvate hydratase

cl21457
Location:70 → 565

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

268073318..268113494

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103299.2 → XP_038959227.1 enolase 4 isoform X8

Conserved Domains (1) summary

cl40480
Location:71 → 273

enolase_like; Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. ...
XM_006231669.5 → XP_006231731.1 enolase 4 isoform X1

UniProtKB/TrEMBL

A0A8I6AN31

Related

ENSRNOP00000063070.4, ENSRNOT00000065289.4

Conserved Domains (2) summary

TIGR01060
Location:68 → 566

eno; phosphopyruvate hydratase

cl21457
Location:70 → 565

TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
XM_017588865.3 → XP_017444354.1 enolase 4 isoform X3

UniProtKB/TrEMBL

D3ZRT2

Related

ENSRNOP00000095223.2, ENSRNOT00000118313.2
XM_017588864.3 → XP_017444353.1 enolase 4 isoform X2

Related

ENSRNOP00000100891.1, ENSRNOT00000158703.1
XM_039103291.2 → XP_038959219.1 enolase 4 isoform X5

Conserved Domains (1) summary

COG0148
Location:66 → 442

Eno; Enolase [Carbohydrate transport and metabolism]
XM_063282814.1 → XP_063138884.1 enolase 4 isoform X6
XM_039103297.2 → XP_038959225.1 enolase 4 isoform X7

Conserved Domains (1) summary

cl40480
Location:45 → 378

enolase_like; Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. ...
XM_063282811.1 → XP_063138881.1 enolase 4 isoform X4
XM_039103296.2 → XP_038959224.1 enolase 4 isoform X7

Conserved Domains (1) summary

cl40480
Location:45 → 378

enolase_like; Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. ...