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    Prrg2 proline rich and Gla domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361570, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prrg2provided by RGD
    Official Full Name
    proline rich and Gla domain 2provided by RGD
    Primary source
    RGD:1305444
    See related
    EnsemblRapid:ENSRNOG00000020517 AllianceGenome:RGD:1305444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Orthologous to human PRRG2 (proline rich and Gla domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 32.7), Lung (RPKM 24.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Prrg2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104670748..104679852, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95534276..95543364, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101046621..101055608, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RAS related Neighboring gene proline rich 12 Neighboring gene nitric oxide synthase interacting protein Neighboring gene reticulocalbin 3 Neighboring gene Fc gamma receptor and transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 2
    Names
    proline rich Gla (G-carboxyglutamic acid) 2
    proline-rich Gla (G-carboxyglutamic acid) polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108482.1 → NP_001101952.1  transmembrane gamma-carboxyglutamic acid protein 2 precursor

      See identical proteins and their annotated locations for NP_001101952.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A6JAW2
      Conserved Domains (1) summary
      smart00069
      Location:33 → 96
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104670748..104679852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759397.4 → XP_008757619.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008757619.1

      UniProtKB/TrEMBL
      A0A0G2K045
      Conserved Domains (1) summary
      smart00069
      Location:33 → 96
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    2. XM_008759396.3 → XP_008757618.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008757618.1

      UniProtKB/TrEMBL
      A0A0G2K045
      Conserved Domains (1) summary
      smart00069
      Location:33 → 96
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    3. XM_063266700.1 → XP_063122770.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K045
      Related
      ENSRNOP00000071298.1, ENSRNOT00000082560.3

    4. XM_039082191.1 → XP_038938119.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K045
      Conserved Domains (1) summary
      smart00069
      Location:33 → 96
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    Nucleotide Protein Strain
    Heading Accession and Version

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