Lrtomt leucine rich transmembrane and O-methyltransferase domain containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrtomtprovided by RGD
Official Full Name: leucine rich transmembrane and O-methyltransferase domain containingprovided by RGD
Primary source: RGD:1561509
See related: EnsemblRapid:ENSRNOG00000023434 AllianceGenome:RGD:1561509
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tomt; RGD1561509
Summary: Predicted to enable catechol O-methyltransferase activity. Predicted to be involved in several processes, including auditory receptor cell development; catecholamine metabolic process; and positive regulation of protein import. Predicted to be located in apical part of cell and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 63. Orthologous to several human genes including LRTOMT (leucine rich transmembrane and O-methyltransferase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 11.8), Testes (RPKM 11.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (165678654..165680703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156266655..156268704, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (166985468..166989681, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128515 (e-PCR)
- UniSTS:211823

RH138736 (e-PCR)
- UniSTS:220823

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables catechol O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables catechol O-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables catechol O-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in catecholamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in catecholamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in catecholamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: transmembrane O-methyltransferase homolog

Names: O-methyltransferase domain containing; catechol O-methyltransferase 2; leucine rich transmembrane and 0-methyltransferase domain containing; protein LRTOMT2

NP_001132966.1

EC 2.1.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001139494.1 → NP_001132966.1 transmembrane O-methyltransferase homolog

See identical proteins and their annotated locations for NP_001132966.1

Status: PROVISIONAL

Source sequence(s)

EU627093

UniProtKB/Swiss-Prot

B6CZ62

Related

ENSRNOP00000036144.4, ENSRNOT00000039564.6

Conserved Domains (1) summary

COG4122
Location:82 → 218

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]