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    Mfap4 microfibril associated protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287382, updated on 27-Dec-2024

    Summary

    Symbol
    Mfap4provided by RGD
    Full Name
    microfibril associated protein 4provided by RGD
    Primary source
    RGD:1307841
    See related
    EnsemblRapid:ENSRNOG00000045683 AllianceGenome:RGD:1307841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Magp-36
    Summary
    Predicted to be involved in elastic fiber assembly; regulation of collagen metabolic process; and response to UV. Predicted to be located in elastic fiber; extracellular region; and microfibril. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 5189.4), Uterus (RPKM 592.7) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Mfap4 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46666552..46669613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46167158..46170176)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (47765463..47768484)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480801 Neighboring gene ring finger protein 112 Neighboring gene uncharacterized LOC120095256 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 domain containing 1 Neighboring gene epsin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC124818

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in UV protection  
    involved_in cellular response to UV-B  
    involved_in elastic fiber assembly  
    involved_in elastic fiber assembly  
    involved_in regulation of collagen metabolic process  
    involved_in supramolecular fiber organization  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix  
    located_in collagen-containing extracellular matrix  
    located_in elastic fiber  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in microfibril  

    General protein information

    Preferred Names
    microfibril-associated glycoprotein 4
    Names
    microfibril-associated glycoprotein 4-like
    microfibrillar-associated protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034124.2 → NP_001029296.2  microfibril-associated glycoprotein 4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HF80, G3V6A9, Q497C9
      Conserved Domains (1) summary
      cd00087
      Location:38 → 256
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46666552..46669613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246560.5 → XP_006246622.1  microfibril-associated glycoprotein 4 isoform X1

      See identical proteins and their annotated locations for XP_006246622.1

      UniProtKB/TrEMBL
      D4A7W8, G3V6A9, Q497C9
      Related
      ENSRNOP00000054690.5, ENSRNOT00000057880.6
      Conserved Domains (1) summary
      cd00087
      Location:38 → 280
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
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