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    Ube2i ubiquitin-conjugating enzyme E2I [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25573, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ube2iprovided by RGD
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by RGD
    Primary source
    RGD:3926
    See related
    EnsemblRapid:ENSRNOG00000066579 AllianceGenome:RGD:3926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ubc9; UbcE2A
    Summary
    Enables bHLH transcription factor binding activity; ionotropic glutamate receptor binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including positive regulation of DNA-binding transcription factor activity; protein sumoylation; and regulation of signal transduction. Located in dendrite and nucleus. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 383.0), Spleen (RPKM 264.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ube2i in Genome Data Viewer
    Location:
    10q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14782245..14802911, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14277749..14294681, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14618615..14639274, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene protease, serine, 34 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105476

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables HLH domain binding  
    enables RING-like zinc finger domain binding  
    enables SUMO conjugating enzyme activity  
    enables SUMO conjugating enzyme activity  
    enables SUMO transferase activity PubMed 
    enables SUMO transferase activity  
    enables bHLH transcription factor binding PubMed 
    enables enzyme binding  
    enables ionotropic glutamate receptor binding PubMed 
    enables protein binding PubMed 
    enables small protein activating enzyme binding  
    enables transcription coregulator binding  
    enables transferase activity  
    enables ubiquitin-protein transferase activity PubMed 
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in chromosome segregation  
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nuclear export  
    involved_in positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of SUMO transferase activity  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of intracellular steroid hormone receptor signaling pathway PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
    involved_in protein sumoylation  
    involved_in protein sumoylation PubMed 
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    involved_in regulation of signaling receptor activity PubMed 
    involved_in ubiquitin-dependent protein catabolic process PubMed 
    Component Evidence Code Pubs
    located_in PML body  
    part_of SUMO ligase complex  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in cytoplasm  
    located_in dendrite PubMed 
    located_in fibrillar center PubMed 
    is_active_in glutamatergic synapse  
    located_in nuclear body PubMed 
    located_in nuclear body  
    located_in nuclear envelope PubMed 
    is_active_in nucleus  
    located_in nucleus  
    is_active_in postsynaptic cytosol  
    is_active_in presynaptic cytosol  
    part_of transferase complex  

    General protein information

    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    RING-type E3 SUMO transferase UBC9
    SUMO-protein ligase
    Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9)
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
    ubiquitin-conjugating enzyme UbcE2A
    ubiquitin-protein ligase I
    NP_037182.1
    XP_006245981.1
    XP_006245982.1
    XP_008765771.3
    XP_017452533.1
    XP_063124544.1
    XP_063124546.1
    XP_063124547.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001428972.1NP_001415901.1  SUMO-conjugating enzyme UBC9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
    2. NM_001428973.1NP_001415902.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
    3. NM_001428974.1NP_001415903.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
    4. NM_001428975.1NP_001415904.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
    5. NM_001428976.1NP_001415905.1  SUMO-conjugating enzyme UBC9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
    6. NM_013050.3NP_037182.1  SUMO-conjugating enzyme UBC9 isoform 1

      See identical proteins and their annotated locations for NP_037182.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P63281
      UniProtKB/TrEMBL
      A6HD16
      Related
      ENSRNOP00000101344.1, ENSRNOT00000154507.1
      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14782245..14802911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268476.1XP_063124546.1  SUMO-conjugating enzyme UBC9 isoform X3

    2. XM_063268474.1XP_063124544.1  SUMO-conjugating enzyme UBC9 isoform X2

    3. XM_008767549.4XP_008765771.3  SUMO-conjugating enzyme UBC9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB55
      Related
      ENSRNOP00000075659.2, ENSRNOT00000090085.3
    4. XM_006245920.5XP_006245982.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    5. XM_017597044.3XP_017452533.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
    6. XM_063268477.1XP_063124547.1  SUMO-conjugating enzyme UBC9 isoform X5

    7. XM_006245919.5XP_006245981.1  SUMO-conjugating enzyme UBC9 isoform X4

      Conserved Domains (1) summary
      pfam00179
      Location:8152
      UQ_con; Ubiquitin-conjugating enzyme
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