Sppl2c signal peptide peptidase like 2C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sppl2cprovided by RGD
Official Full Name: signal peptide peptidase like 2Cprovided by RGD
Primary source: RGD:1560562
See related: EnsemblRapid:ENSRNOG00000005104 AllianceGenome:RGD:1560562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Imp5; RGD1560562
Summary: Predicted to enable aspartic endopeptidase activity, intramembrane cleaving; molecular adaptor activity; and protein homodimerization activity. Predicted to be involved in several processes, including acrosome assembly; fusion of sperm to egg plasma membrane involved in single fertilization; and protein stabilization. Predicted to be active in bounding membrane of organelle and endoplasmic reticulum membrane. Orthologous to human SPPL2C (signal peptide peptidase like 2C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 186.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (89595265..89597470)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (89095279..89097487)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (92245434..92248758)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aspartic endopeptidase activity, intramembrane cleaving	IBA Inferred from Biological aspect of Ancestor more info
enables aspartic endopeptidase activity, intramembrane cleaving	ISO Inferred from Sequence Orthology more info
enables aspartic-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	ISO Inferred from Sequence Orthology more info
involved_in fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
NOT involved_in membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
NOT involved_in membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein intracellular domain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in membrane protein proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi-associated vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasmic side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in lumenal side of endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lumenal side of endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: signal peptide peptidase-like 2C

Names: intramembrane peptidase 5; intramembrane protease 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105847.2 → NP_001099317.1 signal peptide peptidase-like 2C precursor

See identical proteins and their annotated locations for NP_001099317.1

Status: VALIDATED

Source sequence(s)

CV107059, JAXUCZ010000010

UniProtKB/TrEMBL

B1H292, M0R9B3

Related

ENSRNOP00000066080.4, ENSRNOT00000006808.8

Conserved Domains (2) summary

cl01342
Location:250 → 534

Peptidase_A22B; Signal peptide peptidase

cl10459
Location:40 → 177

Peptidases_S8_S53; Peptidase domain in the S8 and S53 families