Slc5a10 solute carrier family 5 member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc5a10provided by RGD
Official Full Name: solute carrier family 5 member 10provided by RGD
Primary source: RGD:1305232
See related: EnsemblRapid:ENSRNOG00000002616 AllianceGenome:RGD:1305232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable D-glucose:sodium symporter activity; fructose:sodium symporter activity; and mannose:sodium symporter activity. Predicted to be involved in D-glucose transmembrane transport; fructose transmembrane transport; and mannose transmembrane transport. Predicted to be active in plasma membrane. Orthologous to human SLC5A10 (solute carrier family 5 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 545.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46851527..46898460, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (46352060..46400795, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47949775..47997802, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knocking Out Sodium Glucose-Linked Transporter 5 Prevents Fructose-Induced Renal Oxidative Stress and Salt-Sensitive Hypertension.
Title: Knocking Out Sodium Glucose-Linked Transporter 5 Prevents Fructose-Induced Renal Oxidative Stress and Salt-Sensitive Hypertension.

Submit: New GeneRIF Correction

General gene information

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Markers

BI289660 (e-PCR)
- UniSTS:246875

BF398725 (e-PCR)
- UniSTS:246900

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucose:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables mannose:sodium symporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fructose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mannose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/mannose cotransporter SLC5A10

Names: sodium/glucose cotransporter 5; solute carrier family 5 (sodium/glucose cotransporter), member 10; solute carrier family 5 (sodium/sugar cotransporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.