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    Gtpbp8 GTP binding protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtpbp8provided by RGD
    Official Full Name
    GTP binding protein 8provided by RGD
    Primary source
    RGD:1310025
    See related
    EnsemblRapid:ENSRNOG00000002044 AllianceGenome:RGD:1310025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310025
    Summary
    Predicted to enable GTP binding activity and metal ion binding activity. Predicted to be active in mitochondrion. Orthologous to human GTPBP8 (GTP binding protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 89.7), Heart (RPKM 74.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtpbp8 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69451776..69461744)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55945778..55955743)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60906990..60916958)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 1 Neighboring gene CD200 receptor 1 Neighboring gene ribosomal oxygenase 2, pseudogene 1 Neighboring gene nucleolus and neural progenitor protein Neighboring gene uncharacterized LOC103693572 Neighboring gene uncharacterized LOC134481000

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108988

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GTP-binding protein 8
    Names
    GTP-binding protein 8 (putative)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025015.1 → NP_001020186.1  GTP-binding protein 8

      See identical proteins and their annotated locations for NP_001020186.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091236
      UniProtKB/Swiss-Prot
      Q5BK22
      UniProtKB/TrEMBL
      A6IQZ8, A6IQZ9
      Related
      ENSRNOP00000002797.3, ENSRNOT00000002797.6
      Conserved Domains (1) summary
      cd01876
      Location:113 → 281
      YihA_EngB; YihA (EngB) GTPase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69451776..69461744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088481.2 → XP_038944409.1  GTP-binding protein 8 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:112 → 171
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_005491038.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK22.1 GenPept UniProtKB/Swiss-Prot:Q5BK22

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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