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    Spta1 spectrin, alpha, erythrocytic 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289257, updated on 27-Dec-2024

    Summary

    Official Symbol
    Spta1provided by RGD
    Official Full Name
    spectrin, alpha, erythrocytic 1provided by RGD
    Primary source
    RGD:1305194
    See related
    EnsemblRapid:ENSRNOG00000003537 AllianceGenome:RGD:1305194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spna1
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including lymphocyte homeostasis; porphyrin-containing compound biosynthetic process; and positive regulation of T cell proliferation. Located in axon and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 3. Orthologous to human SPTA1 (spectrin alpha, erythrocytic 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 408.7), Heart (RPKM 172.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Spta1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (88735833..88811697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (86203504..86279371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (92264231..92340091)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily K member 8 Neighboring gene olfactory receptor family 6 subfamily K member 2 Neighboring gene olfactory receptor family 10 subfamily Z member 1 Neighboring gene olfactory receptor family 10 subfamily X member 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding  
    enables calcium ion binding  
    Component Evidence Code Pubs
    located_in axon PubMed 
    is_active_in cell junction  
    is_active_in cell projection  
    is_active_in cortical actin cytoskeleton  
    located_in cortical cytoskeleton  
    located_in cuticular plate  
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in membrane  
    is_active_in plasma membrane  
    part_of spectrin  
    located_in spectrin-associated cytoskeleton  

    General protein information

    Preferred Names
    spectrin alpha chain, erythrocytic 1
    Names
    erythroid spectrin alpha
    spectrin alpha chain, erythrocyte
    spectrin, alpha, erythrocytic 1 (elliptocytosis 2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011908.4NP_001011908.3  spectrin alpha chain, erythrocytic 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      D4A678, F7FC39, Q6XDA1
      Related
      ENSRNOP00000061853.4, ENSRNOT00000066509.6
      Conserved Domains (6) summary
      smart00150
      Location:900956
      SPEC; Spectrin repeats
      COG5126
      Location:22652379
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd00176
      Location:16061817
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00435
      Location:10801177
      Spectrin; Spectrin repeat
      pfam08726
      Location:23462414
      EFhand_Ca_insen; Ca2+ insensitive EF hand
      cl17036
      Location:9801031
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      88735833..88811697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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