Zar1 zygote arrest 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zar1provided by RGD
Official Full Name: zygote arrest 1provided by RGD
Primary source: RGD:727972
See related: EnsemblRapid:ENSRNOG00000026150 AllianceGenome:RGD:727972
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA sequestering activity; mRNA 3'-UTR binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including oocyte maturation; post-transcriptional regulation of gene expression; and translation. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be active in cytoplasm and intracellular non-membrane-bounded organelle. Orthologous to human ZAR1 (zygote arrest 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 1.7), Brain (RPKM 1.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (35547467..35551757, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (35193446..35197382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (37757579..37764389, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life.
Title: Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA sequestering activity	ISO Inferred from Sequence Orthology more info
enables RNA sequestering activity	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in mRNA stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in membraneless organelle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oocyte maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membraneless organelle	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membraneless organelle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zygote arrest protein 1

Names: oocyte-specific maternal effect factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181385.2 → NP_852050.1 zygote arrest protein 1

See identical proteins and their annotated locations for NP_852050.1

Status: PROVISIONAL

Source sequence(s)

AY283175

UniProtKB/Swiss-Prot

Q7TSX9

UniProtKB/TrEMBL

A6JD55

Related

ENSRNOP00000032032.2, ENSRNOT00000030610.3

Conserved Domains (2) summary

PRK07764
Location:120 → 250

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam13695
Location:264 → 346

zf-3CxxC; Zinc-binding domain