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    Tnfrsf10b TNF receptor superfamily member 10b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364420, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnfrsf10bprovided by RGD
    Official Full Name
    TNF receptor superfamily member 10bprovided by RGD
    Primary source
    RGD:1308041
    See related
    EnsemblRapid:ENSRNOG00000038483 AllianceGenome:RGD:1308041
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and protease binding activity. Involved in extrinsic apoptotic signaling pathway via death domain receptors and male gonad development. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Predicted to be active in plasma membrane raft. Biomarker of colon cancer and osteoarthritis. Human ortholog(s) of this gene implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 18.0), Liver (RPKM 14.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnfrsf10b in Genome Data Viewer
    Location:
    15p11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51249883..51278091)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (44840386..44868318)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51433853..51464215)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene charged multivesicular body protein 7 Neighboring gene Rho-related BTB domain containing 2 Neighboring gene uncharacterized LOC103693695 Neighboring gene uncharacterized LOC102550955

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemopreventive effects of lupulone, a hop {beta}-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Lamy V, et al. Carcinogenesis, 2007 Jul. PMID 17434926
    2. Differential apoptosis gene expression in pediatric tumors of the kidney. Takamizawa S, et al. J Pediatr Surg, 2000 Feb. PMID 10693703
    3. Death receptor response in rodent testis after mono-(2-ethylhexyl) phthalate exposure. Giammona CJ, et al. Toxicol Appl Pharmacol, 2002 Dec 1. PMID 12490136
    4. Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms. Fernàndez V, et al. Haematologica, 2004 Nov. PMID 15531454
    5. Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. McCarthy MM, et al. Clin Cancer Res, 2005 Jul 15. PMID 16033835

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DR5-mediated EGFR-transactivation promotes cardiomyocyte hypertrophic gene transcription.
      Title: Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation.
    2. The present study demonstrates that TRAIL and DR5 were highly expressed in the cerebral cortexes of newborn rats 24 h after hypoxia-ischemia
      Title: Hypoxia-ischemia upregulates TRAIL and TRAIL receptors in the immature rat brain.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables TRAIL binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAIL-activated apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TRAIL-activated apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 10B
    Names
    tumor necrosis factor receptor superfamily, member 10b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395720.2 → NP_001382649.1  tumor necrosis factor receptor superfamily member 10B precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A0G2JZE1, B8YBG7
      Related
      ENSRNOP00000063335.6, ENSRNOT00000066128.6
      Conserved Domains (2) summary
      cd08315
      Location:243 → 329
      Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors
      cd10580
      Location:34 → 133
      TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51249883..51278091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274494.1 → XP_063130564.1  tumor necrosis factor receptor superfamily member 10B isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108873.1: Suppressed sequence

      Description
      NM_001108873.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials