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    Adam5 ADAM metallopeptidase domain 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498654, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adam5provided by RGD
    Official Full Name
    ADAM metallopeptidase domain 5provided by RGD
    Primary source
    RGD:621471
    See related
    EnsemblRapid:ENSRNOG00000017518 AllianceGenome:RGD:621471
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    tMDCII
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in male gonad development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human ADAM5 (ADAM metallopeptidase domain 5 (pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 693.6) See more
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    Genomic context

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    See Adam5 in Genome Data Viewer
    Location:
    16q12.4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (73925345..74001354)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (67223095..67298733)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (72010069..72085666)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene U6 spliceosomal RNA Neighboring gene ADAM metallopeptidase domain 32 Neighboring gene ADAM metallopeptidase domain 3A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ADAM metallopeptidase domain 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Rosselot C, et al. Dev Dyn, 2003 Jul. PMID 12815633
    2. Rat MDC family of proteins: sequence analysis, tissue distribution, and expression in prepubertal and adult rat testis. Frayne J, et al. Mol Reprod Dev, 1997 Oct. PMID 9291465
    3. Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion. Cho C, et al. Genomics, 1996 Jun 15. PMID 8786143
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108772

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male gonad development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disintegrin and metalloproteinase domain-containing protein 5
    Names
    a disintegrin and metallopeptidase domain 5
    a disintegrin and metalloprotease domain (ADAM) 5
    a disintegrin and metalloprotease domain 5
    tMDC II
    transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020303.1 → NP_064699.1  disintegrin and metalloproteinase domain-containing protein 5

      See identical proteins and their annotated locations for NP_064699.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091169
      UniProtKB/Swiss-Prot
      Q5BK84
      UniProtKB/TrEMBL
      A0A0G2K3K9
      Related
      ENSRNOP00000055132.5, ENSRNOT00000058330.6
      Conserved Domains (5) summary
      smart00608
      Location:433 → 576
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:141 → 332
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:355 → 430
      Disintegrin; Disintegrin
      pfam01421
      Location:141 → 334
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:20 → 97
      Pep_M12B_propep; Reprolysin family propeptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      73925345..74001354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275648.1 → XP_063131718.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3K9, A0A140TAH8

    2. XM_006253321.5 → XP_006253383.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3K9, A0A8I6AU58
      Related
      ENSRNOP00000096900.1, ENSRNOT00000102586.2
      Conserved Domains (5) summary
      smart00608
      Location:477 → 620
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:399 → 474
      Disintegrin; Disintegrin
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide

    3. XM_006253322.5 → XP_006253384.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K3K9, A0A140TAH8
      Related
      ENSRNOP00000099898.1, ENSRNOT00000156706.1
      Conserved Domains (5) summary
      smart00608
      Location:477 → 620
      ACR; ADAM Cysteine-Rich Domain
      cd04269
      Location:185 → 376
      ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
      pfam00200
      Location:399 → 474
      Disintegrin; Disintegrin
      pfam01421
      Location:185 → 378
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:35 → 141
      Pep_M12B_propep; Reprolysin family propeptide
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK84.1 GenPept UniProtKB/Swiss-Prot:Q5BK84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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