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    Adh6 alcohol dehydrogenase 6 (class V) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adh6provided by RGD
    Official Full Name
    alcohol dehydrogenase 6 (class V)provided by RGD
    Primary source
    RGD:1306313
    See related
    EnsemblRapid:ENSRNOG00000069176 AllianceGenome:RGD:1306313
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and zinc ion binding activity. Predicted to be involved in retinoic acid metabolic process and retinol metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human ADH6 (alcohol dehydrogenase 6 (class V)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 567.1) See more
    Orthologs
    human all
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    Genomic context

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    See Adh6 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229576612..229608359)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226903208..226934564)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243656568..243687857)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6A (class V) Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide, pseudogene 1 Neighboring gene uncharacterized LOC108350123 Neighboring gene uncharacterized LOC134485688 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene. Chen CS, et al. Biochem Biophys Res Commun, 1991 Dec 16. PMID 1755855
    2. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Lange LG, et al. Biochemistry, 1976 Oct 19. PMID 9982
    3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ethanol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinoic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alcohol dehydrogenase 6
    Names
    class V alcohol dehydrogenase
    NP_001012084.1
    XP_006233436.1
    XP_017446428.1
    XP_038958396.1
    XP_063138044.1
    XP_063138045.1
    XP_063138046.1
    XP_063138047.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012084.1 → NP_001012084.1  alcohol dehydrogenase 6

      See identical proteins and their annotated locations for NP_001012084.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083792
      UniProtKB/Swiss-Prot
      Q5XI95
      UniProtKB/TrEMBL
      A0A8I6A108
      Related
      ENSRNOP00000030638.6, ENSRNOT00000036993.6
      Conserved Domains (2) summary
      cd08299
      Location:3 → 376
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:8 → 374
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      229576612..229608359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281974.1 → XP_063138044.1  alcohol dehydrogenase 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A108, A0A8I6ATS6

    2. XM_063281976.1 → XP_063138046.1  alcohol dehydrogenase 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLG2, A0A8I6A108

    3. XM_063281975.1 → XP_063138045.1  alcohol dehydrogenase 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLG2, A0A8I6A108

    4. XM_006233374.3 → XP_006233436.1  alcohol dehydrogenase 6 isoform X3

      See identical proteins and their annotated locations for XP_006233436.1

      UniProtKB/TrEMBL
      A0A8I6A108, A0A8L2QGL3
      Related
      ENSRNOP00000097057.2, ENSRNOT00000106556.2
      Conserved Domains (2) summary
      cd08299
      Location:20 → 389
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
      COG1062
      Location:21 → 387
      FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

    5. XM_063281977.1 → XP_063138047.1  alcohol dehydrogenase 6 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A108

    6. XM_017590939.3 → XP_017446428.1  alcohol dehydrogenase 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLG2, A0A8I6A108
      Conserved Domains (1) summary
      cd08299
      Location:22 → 392
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

    7. XM_039102468.2 → XP_038958396.1  alcohol dehydrogenase 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLG2, A0A8I6A108
      Conserved Domains (1) summary
      cd08299
      Location:22 → 392
      alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

    RNA

    1. XR_010063619.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI95.1 GenPept UniProtKB/Swiss-Prot:Q5XI95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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