Nnt nicotinamide nucleotide transhydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nntprovided by RGD
Official Full Name: nicotinamide nucleotide transhydrogenaseprovided by RGD
Primary source: RGD:1587346
See related: EnsemblRapid:ENSRNOG00000026842 AllianceGenome:RGD:1587346
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NADP binding activity. Involved in several processes, including cell redox homeostasis; intracellular oxygen homeostasis; and positive regulation of hydrogen peroxide catabolic process. Predicted to be located in mitochondrion. Biomarker of obesity. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 2590.3), Muscle (RPKM 852.4) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q15

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (53144157..53237857, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (51411413..51505125, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (52189523..52283095, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nnt is the critical link between the metabolic and H2O2 antioxidant function in brain mitochondria and is a potential therapeutic target to improve the redox balance in conditions of oxidative stress associated with neurodegenerative diseases.
Title: Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) system.
Disruption of electron flux from fuel substrates to redox components due to NNT suppression induces not only mitochondrial dysfunction but also cellular disorders through redox-sensitive signaling.
Title: Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128163 (e-PCR)
- UniSTS:211471

RH139449 (e-PCR)
- UniSTS:221535

D2Rat318 (e-PCR), detects polymorphism
- UniSTS:227451

BE117824 (e-PCR)
- UniSTS:248720

BE115925 (e-PCR)
- UniSTS:248246

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables proton-translocating NAD(P)+ transhydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in NADPH regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular oxidant detoxification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular oxygen homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hydrogen peroxide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD(P) transhydrogenase, mitochondrial

Names: Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

NP_001013175.1

EC 7.1.1.1

XP_006232030.1

EC 7.1.1.1

XP_006232031.1

EC 7.1.1.1

XP_006232032.1

EC 7.1.1.1

XP_006232033.1

EC 7.1.1.1

XP_006232034.1

EC 7.1.1.1

XP_008758996.1

EC 7.1.1.1

XP_038958184.1

EC 7.1.1.1

XP_038958185.1

EC 7.1.1.1

XP_063137853.1

EC 7.1.1.1

XP_063137854.1

EC 7.1.1.1

XP_063137855.1

EC 7.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013157.1 → NP_001013175.1 NAD(P) transhydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_001013175.1

Status: PROVISIONAL

Source sequence(s)

BC091271

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Related

ENSRNOP00000029578.3, ENSRNOT00000033627.5

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

53144157..53237857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281783.1 → XP_063137853.1 NAD(P) transhydrogenase, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6AC81, A0A8I6ALS9
XM_008760774.3 → XP_008758996.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_008758996.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_006231968.5 → XP_006232030.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006232030.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_006231969.5 → XP_006232031.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006232031.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_063281785.1 → XP_063137855.1 NAD(P) transhydrogenase, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6AC81, A0A8I6ALS9

Related

ENSRNOP00000090631.1, ENSRNOT00000108201.2
XM_006231972.5 → XP_006232034.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006232034.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_063281784.1 → XP_063137854.1 NAD(P) transhydrogenase, mitochondrial isoform X4

UniProtKB/TrEMBL

A0A8I6AC81, A0A8I6ALS9
XM_006231971.5 → XP_006232033.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006232033.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_006231970.5 → XP_006232032.1 NAD(P) transhydrogenase, mitochondrial isoform X2

See identical proteins and their annotated locations for XP_006232032.1

UniProtKB/TrEMBL

A0A8I6A0P0, Q5BJZ3

Conserved Domains (4) summary

PRK09424
Location:57 → 587

pntA; NAD(P) transhydrogenase subunit alpha; Provisional

cd05304
Location:57 → 432

Rubrum_tdh; Rubrum transdehydrogenase NAD-binding and catalytic domains

pfam02233
Location:622 → 1079

PNTB; NAD(P) transhydrogenase beta subunit

pfam12769
Location:502 → 587

PNTB_4TM; 4TM region of pyridine nucleotide transhydrogenase, mitoch
XM_039102256.2 → XP_038958184.1 NAD(P) transhydrogenase, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6A0P0, A0A8I6AQG5

Related

ENSRNOP00000085139.2, ENSRNOT00000103489.2

Conserved Domains (2) summary

PRK09424
Location:112 → 642

pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha

pfam02233
Location:677 → 1134

PNTB; NAD(P) transhydrogenase beta subunit
XM_039102257.2 → XP_038958185.1 NAD(P) transhydrogenase, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8I6A0P0

Conserved Domains (2) summary

PRK09424
Location:112 → 578

pntA; Re/Si-specific NAD(P)(+) transhydrogenase subunit alpha

pfam02233
Location:613 → 1070

PNTB; NAD(P) transhydrogenase beta subunit