Ass1 argininosuccinate synthase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ass1provided by RGD
Official Full Name: argininosuccinate synthase 1provided by RGD
Primary source: RGD:2163
See related: EnsemblRapid:ENSRNOG00000008837 AllianceGenome:RGD:2163
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ass; ASSA
Summary: Enables argininosuccinate synthase activity and toxic substance binding activity. Involved in several processes, including L-amino acid metabolic process; cellular response to cAMP; and cellular response to cytokine stimulus. Located in cell body fiber; mitochondrial outer membrane; and perikaryon. Biomarker of uveitis. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 4518.0) and Kidney (RPKM 3204.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35144765..35194632)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14747355..14796909)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (10327411..10375847, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these studies demonstrate that increased amino acid flux can activate AMPK through increased AMP generated by ASS, thus providing a novel link between protein catabolism, ureagenesis, and hepatic lipid metabolism.
Title: Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.
Local factors such as the NO produced by nNOS/ASS/ASL-positive neurons, could influence ASS/ASL-positive microglia cells avoiding or allowing the induction, in these cells, of iNOS.
Title: Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia.
Argininosuccinate synthetase has a role in preventing autotoxicity from nitric oxide overproduction
Title: Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo.
The latter, in turn, attenuates L-arg catabolism and urea production and, thereby, mitigates the fall in plasma L-arg.
Title: Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.
24 h after reperfusion, number of nNOS-positive neurons and tpercentage of those co-expressing ASS and ASL were significantly increased in the animals with a longer survival. 144 h after ischemia there was almost complete restore of these neurons.
Title: Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ass1 (e-PCR), detects polymorphism
- UniSTS:506742

RH94456 (e-PCR)
- UniSTS:119704

RH136340 (e-PCR)
- UniSTS:210330

D3Chm42 (e-PCR)
- UniSTS:265387

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables amino acid binding	ISO Inferred from Sequence Orthology more info
enables argininosuccinate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables argininosuccinate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables argininosuccinate synthase activity	IEA Inferred from Electronic Annotation more info
enables argininosuccinate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables argininosuccinate synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in L-arginine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-arginine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-arginine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-arginine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-arginine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in acute-phase response	IEP Inferred from Expression Pattern more info	PubMed
involved_in argininosuccinate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in argininosuccinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in argininosuccinate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in aspartate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amine stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to amino acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to ammonium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucagon stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to laminar fluid shear stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to oleic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in citrulline metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diaphragm development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in midgut development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fatty acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mycotoxin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to zinc ion	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in urea cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in urea cycle	IEA Inferred from Electronic Annotation more info
involved_in urea cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in urea cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: argininosuccinate synthase

Names: argininosuccinate synthetase 1; arginosuccinate synthetase 1; citrulline--aspartate ligase

NP_037289.1

EC 6.3.4.5

XP_006233973.1

EC 6.3.4.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.