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    Zbtb46 zinc finger and BTB domain containing 46 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311718, updated on 9-Dec-2024

    Summary

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    Symbol
    Zbtb46provided by RGD
    Full Name
    zinc finger and BTB domain containing 46provided by RGD
    Primary source
    RGD:1307408
    See related
    EnsemblRapid:ENSRNOG00000014592 AllianceGenome:RGD:1307408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Btbd4
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of leukocyte activation and regulation of leukocyte differentiation. Predicted to be located in chromatin. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 83.2), Lung (RPKM 72.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb46 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (188874826..188949005, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168497294..168567799, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (176888502..176959009, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SLC2A4 regulator Neighboring gene Lck interacting transmembrane adaptor 1 Neighboring gene RNA, U6 small nuclear 663 Neighboring gene uncharacterized LOC120101834 Neighboring gene abhydrolase domain containing 16B Neighboring gene TPD52 like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. Satpathy AT, et al. J Exp Med, 2012 Jun 4. PMID 22615127, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of granulocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of leukocyte activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of plasmacytoid dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 46
    Names
    BTB (POZ) domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107808.2 → NP_001101278.1  zinc finger and BTB domain-containing protein 46 isoform 1

      See identical proteins and their annotated locations for NP_001101278.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6KM10, D3ZTY1
      Related
      ENSRNOP00000020168.4, ENSRNOT00000020168.8
      Conserved Domains (5) summary
      smart00225
      Location:32 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:362 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001434154.1 → NP_001421083.1  zinc finger and BTB domain-containing protein 46 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JXJ5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      188874826..188949005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283896.1 → XP_063139966.1  zinc finger and BTB domain-containing protein 46 isoform X1

      UniProtKB/TrEMBL
      A6KM10, D3ZTY1

    2. XM_008762510.4 → XP_008760732.1  zinc finger and BTB domain-containing protein 46 isoform X1

      Conserved Domains (5) summary
      smart00225
      Location:32 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:362 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:421 → 441
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:21 → 126
      BTB; BTB/POZ domain
      pfam13465
      Location:434 → 458
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_005501903.2 RNA Sequence

    2. XR_005501902.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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