Plppr1 phospholipid phosphatase related 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plppr1provided by RGD
Official Full Name: phospholipid phosphatase related 1provided by RGD
Primary source: RGD:1303116
See related: EnsemblRapid:ENSRNOG00000007575 AllianceGenome:RGD:1303116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lppr1; Prg-3
Summary: Predicted to enable phosphatidate phosphatase activity. Involved in nervous system development. Located in neuron projection and plasma membrane. Orthologous to human PLPPR1 (phospholipid phosphatase related 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 34.7), Liver (RPKM 13.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (68232963..68520784)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (63437457..63725286)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (67852817..67985310, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRG-3 is expressed in brain and shows a specific expression pattern during brain development and is found mostly in neuronal cell layers and expressed at embryonic day 16. In mature brain strongest PRG-3 expression occurs in hippocampus and cerebellum
Title: Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family.

Submit: New GeneRIF Correction

General gene information

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Markers

BF399287 (e-PCR)
- UniSTS:247600

BF386979 (e-PCR)
- UniSTS:243901

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables lysophosphatidic acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in phospholipid dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipid phosphatase-related protein type 1

Names: inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; plasticity related gene 3; plasticity-related gene 3 protein; plasticity-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201271.3 → NP_958428.2 phospholipid phosphatase-related protein type 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q6WAY2

UniProtKB/TrEMBL

F1LR11

Related

ENSRNOP00000009987.3, ENSRNOT00000009987.6

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...