Nt5c1a 5'-nucleotidase, cytosolic IA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nt5c1aprovided by RGD
Official Full Name: 5'-nucleotidase, cytosolic IAprovided by RGD
Primary source: RGD:1310908
See related: EnsemblRapid:ENSRNOG00000068555 AllianceGenome:RGD:1310908
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 5'-nucleotidase activity. Involved in adenosine metabolic process. Predicted to be active in cytosol. Orthologous to human NT5C1A (5'-nucleotidase, cytosolic IA). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 248.6), Heart (RPKM 77.1) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140758219..140782706)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135473107..135494400)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140888862..140909322)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Al increases NTPDase and 5'-nucleotidase activities, in synaptosomal fractions and platelets. Thus, we suggest that platelets could be sensitive peripheral markers of Al toxicity of the central nervous system.
Title: The effect of aluminium on NTPDase and 5'-nucleotidase activities from rat synaptosomes and platelets.

Submit: New GeneRIF Correction

General gene information

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Markers

Nt5c1a (e-PCR), detects polymorphism
- UniSTS:546903

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables IMP 5'-nucleotidase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in IMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in adenosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in allantoin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dAMP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGMP catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within purine nucleoside monophosphate catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytosolic 5'-nucleotidase 1A

NP_001101446.1

EC 3.1.3.5

XP_017448888.1

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.