Plk3 polo-like kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plk3provided by RGD
Official Full Name: polo-like kinase 3provided by RGD
Primary source: RGD:62039
See related: EnsemblRapid:ENSRNOG00000018484 AllianceGenome:RGD:62039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cnk; Fnk
Summary: Predicted to enable p53 binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; positive regulation of protein catabolic process; and regulation of cell cycle process. Located in dendrite and neuronal cell body. Orthologous to human PLK3 (polo like kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 39.2), Spleen (RPKM 33.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135843725..135848900, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (130607142..130612317, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135997725..136002900, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy.
Title: PLK-3-mediated phosphorylation of BAP1 prevents diabetic retinopathy.
the increase in Plk2 and Plk3 expression contributes to the cell cycle arrest of granulosa cells which is important for the luteinization of granulosa cells during the periovulatory period.
Title: Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in Golgi disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G1/S transition checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G1/S transition checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G1/S transition checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to radiation	ISO Inferred from Sequence Orthology more info
involved_in response to radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK3

Names: FGF-inducible kinase; PLK-3; cytokine inducible kinase; cytokine-inducible serine/threonine-protein kinase; serine-threonine kinase

NP_071523.1

EC 2.7.11.21

XP_038966622.1

EC 2.7.11.21

XP_038966623.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022187.1 → NP_071523.1 serine/threonine-protein kinase PLK3

See identical proteins and their annotated locations for NP_071523.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q9R011

UniProtKB/TrEMBL

A6JZC5

Related

ENSRNOP00000025197.5, ENSRNOT00000025197.7

Conserved Domains (4) summary

smart00220
Location:62 → 314

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:562 → 629

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:461 → 549

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14189
Location:60 → 314

STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

135843725..135848900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110694.1 → XP_038966622.1 serine/threonine-protein kinase PLK3 isoform X1

Conserved Domains (3) summary

cd13117
Location:366 → 433

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:265 → 353

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl21453
Location:1 → 118

PKc_like; Protein Kinases, catalytic domain
XM_039110695.2 → XP_038966623.1 serine/threonine-protein kinase PLK3 isoform X2

UniProtKB/TrEMBL

A6JZC6

Conserved Domains (1) summary

cl21453
Location:60 → 314

PKc_like; Protein Kinases, catalytic domain