Prss44 serine protease 44 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prss44provided by RGD
Official Full Name: serine protease 44provided by RGD
Primary source: RGD:1560940
See related: EnsemblRapid:ENSRNOG00000030073 AllianceGenome:RGD:1560940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tessp4; RGD1560940
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in germ cell development; proteolysis; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human PRSS44P (serine protease 44, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 33.8) See more
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Genomic context

Location:: 8q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (119670088..119683717)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110791698..110805303)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (119083900..119097707)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in germ cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine protease 44

Names: protease, serine, 44; testis serine protease 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109298.2 → NP_001102768.2 serine protease 44 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I3H0, E9PSW9

Related

ENSRNOP00000044953.4, ENSRNOT00000051947.7
NM_001401228.1 → NP_001388157.1 serine protease 44 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I3H1, B5DF96, D4A5V1

Related

ENSRNOP00000047186.5, ENSRNOT00000048655.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

119670088..119683717

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766648.4 → XP_008764870.1 serine protease 44 isoform X1

Conserved Domains (2) summary

smart00020
Location:10 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:11 → 239

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...