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    Nek11 NIMA-related kinase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315978, updated on 4-Jan-2025

    Summary

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    Symbol
    Nek11provided by RGD
    Full Name
    NIMA-related kinase 11provided by RGD
    Primary source
    RGD:1308801
    See related
    EnsemblRapid:ENSRNOG00000042432 AllianceGenome:RGD:1308801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitotic intra-S DNA damage checkpoint signaling; protein phosphorylation; and regulation of mitotic cell cycle phase transition. Predicted to be located in nucleolus and nucleoplasm. Orthologous to human NEK11 (NIMA related kinase 11). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Testes (RPKM 38.4), Lung (RPKM 17.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek11 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (114646010..114905242, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (105767230..106026676, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (113703406..113937097, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 16 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene microRNA 6330 Neighboring gene spermine synthase, pseudogene 1 Neighboring gene asteroid homolog 1 Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. Melixetian M, et al. Nat Cell Biol, 2009 Oct. PMID 19734889
    2. Nek11, a new member of the NIMA family of kinases, involved in DNA replication and genotoxic stress responses. Noguchi K, et al. J Biol Chem, 2002 Oct 18. PMID 12154088
    3. Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells. Noguchi K, et al. J Biol Chem, 2004 Jul 30. PMID 15161910
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek11
    Names
    NIMA (never in mitosis gene a)- related kinase 11
    NIMA (never in mitosis gene a)-related expressed kinase 11
    NP_001400753.1
    XP_008764752.1
    XP_017451170.1
    XP_017451175.1
    XP_017451176.1
    XP_038937489.1
    XP_038937490.1
    XP_038937493.1
    XP_038937494.1
    XP_038937495.1
    XP_063121679.1
    XP_063121680.1
    XP_063121682.1
    XP_063121683.1
    XP_063121684.1
    XP_063121685.1
    XP_063121686.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413824.1 → NP_001400753.1  serine/threonine-protein kinase Nek11

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AI15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      114646010..114905242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595687.3 → XP_017451176.1  serine/threonine-protein kinase Nek11 isoform X4

    2. XM_039081562.2 → XP_038937490.1  serine/threonine-protein kinase Nek11 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:28 → 202
      PKc_like; Protein Kinases, catalytic domain

    3. XM_063265610.1 → XP_063121680.1  serine/threonine-protein kinase Nek11 isoform X3

    4. XM_017595681.3 → XP_017451170.1  serine/threonine-protein kinase Nek11 isoform X2

    5. XM_063265609.1 → XP_063121679.1  serine/threonine-protein kinase Nek11 isoform X1

      Related
      ENSRNOP00000093100.2, ENSRNOT00000107138.2

    6. XM_063265616.1 → XP_063121686.1  serine/threonine-protein kinase Nek11 isoform X13

      UniProtKB/TrEMBL
      D4A3H8
      Related
      ENSRNOP00000047201.4, ENSRNOT00000046816.5

    7. XM_008766530.4 → XP_008764752.1  serine/threonine-protein kinase Nek11 isoform X14

      Conserved Domains (2) summary
      smart00220
      Location:27 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08222
      Location:26 → 285
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    8. XM_017595686.3 → XP_017451175.1  serine/threonine-protein kinase Nek11 isoform X4

    9. XM_063265614.1 → XP_063121684.1  serine/threonine-protein kinase Nek11 isoform X9

    10. XM_063265613.1 → XP_063121683.1  serine/threonine-protein kinase Nek11 isoform X8

    11. XM_039081565.2 → XP_038937493.1  serine/threonine-protein kinase Nek11 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:1 → 63
      PKc_like; Protein Kinases, catalytic domain

    12. XM_039081561.2 → XP_038937489.1  serine/threonine-protein kinase Nek11 isoform X5

      UniProtKB/TrEMBL
      A6I2N1
      Conserved Domains (1) summary
      cd08222
      Location:26 → 285
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    13. XM_063265612.1 → XP_063121682.1  serine/threonine-protein kinase Nek11 isoform X7

      UniProtKB/TrEMBL
      A6I2N1

    14. XM_063265615.1 → XP_063121685.1  serine/threonine-protein kinase Nek11 isoform X10

    15. XM_039081567.2 → XP_038937495.1  serine/threonine-protein kinase Nek11 isoform X12

      Conserved Domains (1) summary
      cd08222
      Location:26 → 285
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11

    16. XM_039081566.2 → XP_038937494.1  serine/threonine-protein kinase Nek11 isoform X11

      Conserved Domains (1) summary
      cd08222
      Location:26 → 285
      STKc_Nek11; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
    Nucleotide Protein Strain
    Heading Accession and Version

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