U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nrp2 neuropilin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81527, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrp2provided by RGD
    Official Full Name
    neuropilin 2provided by RGD
    Primary source
    RGD:621442
    See related
    EnsemblRapid:ENSRNOG00000031232 AllianceGenome:RGD:621442
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and semaphorin receptor activity. Involved in axon guidance. Predicted to be located in membrane. Predicted to be active in axon; glutamatergic synapse; and postsynaptic membrane. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 127.6), Heart (RPKM 80.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nrp2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (71616602..71731869)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64122815..64238007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69496875..69609802)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene par-3 family cell polarity regulator beta Neighboring gene uncharacterized LOC134480584 Neighboring gene uncharacterized LOC134480583 Neighboring gene uncharacterized LOC134480585 Neighboring gene uncharacterized LOC102548410 Neighboring gene ribosomal protein L37, pseudogene 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding  
    enables identical protein binding  
    enables metal ion binding  
    enables semaphorin receptor activity  
    enables semaphorin receptor activity  
    enables semaphorin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in axon extension involved in axon guidance  
    involved_in axon extension involved in axon guidance  
    involved_in axon guidance  
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    acts_upstream_of_or_within axon guidance  
    involved_in cellular response to leukemia inhibitory factor  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor  
    involved_in dorsal root ganglion morphogenesis  
    involved_in dorsal root ganglion morphogenesis  
    involved_in facial nerve structural organization  
    involved_in facial nerve structural organization  
    involved_in facioacoustic ganglion development  
    involved_in facioacoustic ganglion development  
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus  
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus  
    acts_upstream_of_or_within heart development  
    involved_in negative chemotaxis  
    acts_upstream_of_or_within negative chemotaxis  
    involved_in nerve development  
    involved_in neural crest cell migration involved in autonomic nervous system development  
    involved_in neural crest cell migration involved in autonomic nervous system development  
    involved_in neuron migration  
    involved_in outflow tract septum morphogenesis  
    involved_in outflow tract septum morphogenesis  
    involved_in regulation of postsynapse organization  
    involved_in regulation of postsynapse organization  
    involved_in semaphorin-plexin signaling pathway  
    involved_in semaphorin-plexin signaling pathway  
    involved_in sensory neuron axon guidance  
    involved_in sensory neuron axon guidance  
    involved_in sympathetic ganglion development  
    involved_in sympathetic ganglion development  
    involved_in sympathetic neuron projection extension  
    involved_in sympathetic neuron projection extension  
    involved_in sympathetic neuron projection guidance  
    involved_in sympathetic neuron projection guidance  
    involved_in trigeminal ganglion development  
    involved_in trigeminal ganglion development  
    acts_upstream_of_or_within trunk neural crest cell migration  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in ventral trunk neural crest cell migration  
    involved_in ventral trunk neural crest cell migration  
    involved_in vestibulocochlear nerve structural organization  
    involved_in vestibulocochlear nerve structural organization  
    Items 1 - 25 of 46
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon  
    located_in axon  
    is_active_in glutamatergic synapse  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in membrane  
    is_active_in plasma membrane  
    is_active_in postsynaptic membrane  
    located_in postsynaptic membrane  
    is_active_in postsynaptic membrane  

    General protein information

    Preferred Names
    neuropilin-2
    Names
    vascular endothelial cell growth factor 165 receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030869.4NP_110496.1  neuropilin-2 precursor

      See identical proteins and their annotated locations for NP_110496.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      O35276
      UniProtKB/TrEMBL
      A0A8I6A5P1
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:846922
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      71616602..71731869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245039.5XP_006245101.1  neuropilin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5P1, A0A8I6AF12
      Related
      ENSRNOP00000090812.1, ENSRNOT00000105009.2
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:851927
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    2. XM_008767137.4XP_008765359.1  neuropilin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5P1, A0A8L2UM12
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:834910
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. XM_006245040.5XP_006245102.1  neuropilin-2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5P1
      Related
      ENSRNOP00000047206.4, ENSRNOT00000042562.5
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:829905
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. XM_006245041.5XP_006245103.1  neuropilin-2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A5P1, A0A8I6AH16
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:822901
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    5. XM_006245042.5XP_006245104.1  neuropilin-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5P1
      Related
      ENSRNOP00000094102.2, ENSRNOT00000119267.2
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:817896
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. XM_039084243.2XP_038940171.1  neuropilin-2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A5P1
      Conserved Domains (3) summary
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    External link. Please review our privacy policy.