Trip10 thyroid hormone receptor interactor 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trip10provided by RGD
Official Full Name: thyroid hormone receptor interactor 10provided by RGD
Primary source: RGD:621145
See related: EnsemblRapid:ENSRNOG00000055524 AllianceGenome:RGD:621145
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: STP; Cip4
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; positive regulation of cell growth involved in cardiac muscle cell development; and response to food. Predicted to be located in nucleoplasm. Orthologous to human TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 214.8), Heart (RPKM 141.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (2219695..2234771)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (2133085..2147795)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (9689214..9702353, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that the CIP4/Par6 complex plays an important role in the occurrence of epithelial-mesenchymal transition in TGF-beta1-stimulated epithelial kidney cells.
Title: Suppression of CIP4/Par6 attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells.
Calcitriol may protect diabetic nephropathy from fibrosis via inhibition of TGF-beta1 and CIP4.
Title: Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-β1 and CIP4 in diabetic nephropathy rat.
ARHGAP12 negatively controls dendritic spine size via its RhoGAP activity and promotes, by interacting with CIP4, postsynaptic AMPA receptor endocytosis.
Title: ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse Function.
CIP4 overexpression represses E-cadherin expression by promoting beta-catenin translocation to the nucleus.
Title: Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells.
CIP4 is capable of inducing ECM deposition and exacerbating progressive fibrosis in chronic renal failure.
Title: Cdc42-interacting protein-4 promotes TGF-Β1-induced epithelial-mesenchymal transition and extracellular matrix deposition in renal proximal tubular epithelial cells.
Results support a previously unrecognized role for CIP4 in GLUT4 endocytosis, and show that interactions between CIP4 and Dynamin-2 and between CIP4 and NWASp are spatially coordinated to promote function.
Title: The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2.
High-fat diet might have a relevance to insulin resistance by increasing the expression of PP2A and suppressing the expression of TC10 and CIP4 in the insulin-signaling cascade in the visceral adipose tissue.
Title: High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats.
a new role for Trip10, showing that the level of Trip10 expression is associated with the maintenance and differentiation of MSCs, was established.
Title: DNA methylation of the Trip10 promoter accelerates mesenchymal stem cell lineage determination.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth involved in cardiac muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cdc42-interacting protein 4

Names: TR-interacting protein 10; TRIP-10; salt tolerant protein; thyroid receptor-interacting protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432354.1 → NP_001419283.1 cdc42-interacting protein 4 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AQN3
NM_001432355.1 → NP_001419284.1 cdc42-interacting protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A4V0
NM_001432359.1 → NP_001419288.1 cdc42-interacting protein 4 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AQN3
NM_001432361.1 → NP_001419290.1 cdc42-interacting protein 4 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A4V0
NM_001432362.1 → NP_001419291.1 cdc42-interacting protein 4 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6A4V0
NM_053920.3 → NP_446372.2 cdc42-interacting protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

P97531, Q6P744

UniProtKB/TrEMBL

A0A8I6A4V0

Related

ENSRNOP00000085991.1, ENSRNOT00000094803.2

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:339 → 419

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11777
Location:490 → 544

SH3_CIP4_Bzz1_like; Src Homology 3 domain of Cdc42-Interacting Protein 4, Bzz1 and similar domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

2219695..2234771

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082908.2 → XP_038938836.1 cdc42-interacting protein 4 isoform X1

Related

ENSRNOP00000096332.1, ENSRNOT00000102687.2

Conserved Domains (3) summary

cd07653
Location:5 → 257

F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins

cd11628
Location:395 → 475

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:546 → 600

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
XM_039082910.2 → XP_038938838.1 cdc42-interacting protein 4 isoform X2

Conserved Domains (3) summary

cd11628
Location:287 → 367

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:438 → 492

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

cl12013
Location:1 → 149

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039082909.2 → XP_038938837.1 cdc42-interacting protein 4 isoform X2

UniProtKB/TrEMBL

A0A8I6AQN3

Conserved Domains (3) summary

cd11628
Location:287 → 367

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:438 → 492

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

cl12013
Location:1 → 149

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_039082911.2 → XP_038938839.1 cdc42-interacting protein 4 isoform X3

Conserved Domains (3) summary

cd11628
Location:231 → 311

HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like

cd11911
Location:382 → 436

SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

cl12013
Location:1 → 149

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature