Gpr119 G protein-coupled receptor 119 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr119provided by RGD
Official Full Name: G protein-coupled receptor 119provided by RGD
Primary source: RGD:727808
See related: EnsemblRapid:ENSRNOG00000024517 AllianceGenome:RGD:727808
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity and phosphatidylcholine binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within insulin secretion. Predicted to be part of receptor complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR119 (G protein-coupled receptor 119). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 6.3), Spleen (RPKM 1.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (132730027..132736080, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (127852145..127858198, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (135515545..135521598, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results demonstrate that the neural coordination between the the gustatory and gastrointestinal insula is generated or suppressed by the opposing activities between CB1R and GPR119.
Title: A role of CB1R in inducing θ-rhythm coordination between the gustatory and gastrointestinal insula.
Angelica dahurica extract-treated cells showed significant increases in GPR119 activation, intracellular cAMP levels, GLP-1 levels and glucose-stimulated insulin secretion as compared with controls
Title: Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.
Pathways activated in response to GPR119 modulation in cardiac muscle cells differ between healthy and metabolically dysregulated states.
Title: Direct activation of the proposed anti-diabetic receptor, GPR119 in cardiomyoblasts decreases markers of muscle metabolic activity.
Results show that functional GPR119 responses are similar in lean and diabetic rodent, and human colon; that GPR119 stimulation can result in glucose lowering through release of intestinal peptide hormones.
Title: Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes.
Data suggest that GPR119 activation/up-regulation in skeletal muscle impairs fatty acid and glucose oxidation; diet-induced obesity appears to up-regulate skeletal muscle GPR119.
Title: GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glucose-dependent insulinotropic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181770.1 → NP_861435.1 glucose-dependent insulinotropic receptor

See identical proteins and their annotated locations for NP_861435.1

Status: PROVISIONAL

Source sequence(s)

AY288429

UniProtKB/Swiss-Prot

Q7TQN8

UniProtKB/TrEMBL

A6JMR2

Related

ENSRNOP00000036164.3, ENSRNOT00000033619.5

Conserved Domains (2) summary

cd15104
Location:6 → 290

7tmA_GPR119_R_insulinotropic_receptor; G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

cd21575
Location:346 → 453

KLF18_N; N-terminal domain of Kruppel-like factor 18