U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Neurl2 neuralized E3 ubiquitin protein ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311633, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Neurl2provided by RGD
    Official Full Name
    neuralized E3 ubiquitin protein ligase 2provided by RGD
    Primary source
    RGD:1306409
    See related
    EnsemblRapid:ENSRNOG00000015797 AllianceGenome:RGD:1306409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to act upstream of or within sarcomere organization. Predicted to be located in muscle tendon junction. Predicted to be part of VCB complex. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 133.2), Heart (RPKM 91.0) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Neurl2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173985996..173988717, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153566659..153569380, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161296303..161299024, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger, SWIM-type containing 3 Neighboring gene zinc finger, SWIM-type containing 1 Neighboring gene spermatogenesis associated 25 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene phosphorylated CTD interacting factor 1 like 1 Neighboring gene phosphorylated CTD interacting factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Nastasi T, et al. Dev Cell, 2004 Feb. PMID 14960280
    2. Regulation of notch signaling activity. Schweisguth F. Curr Biol, 2004 Feb 3. PMID 14986688
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of VCB complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in muscle tendon junction ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    neuralized-like protein 2
    Names
    neuralized homolog 2
    neuralized-like 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107802.2 → NP_001101272.1  neuralized-like protein 2

      See identical proteins and their annotated locations for NP_001101272.1

      Status: VALIDATED

      Source sequence(s)
      BC158617
      UniProtKB/TrEMBL
      A6JXC1, B0BMZ0, F7FB77
      Conserved Domains (2) summary
      smart00969
      Location:249 → 285
      SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases
      cd12887
      Location:25 → 242
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173985996..173988717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283871.1 → XP_063139941.1  neuralized-like protein 2 isoform X1

      Related
      ENSRNOP00000021217.5, ENSRNOT00000021216.7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous