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    Gsta3 glutathione S-transferase alpha 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494500, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Gsta3provided by RGD
    Official Full Name
    glutathione S-transferase alpha 3provided by RGD
    Primary source
    RGD:1591980
    See related
    EnsemblRapid:ENSRNOG00000056847 AllianceGenome:RGD:1591980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Yc2; Gsta5
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human GSTA5 (glutathione S-transferase alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 1222.7), Adrenal (RPKM 500.3) and 3 other tissues See more
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    Genomic context

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    See Gsta3 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (31154989..31180653)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (23658574..23684240)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (27357490..27417023)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550123 Neighboring gene glutathione S-transferase alpha 3 like 1 Neighboring gene transmembrane protein 14A Neighboring gene makorin ring finger protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108351903 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione S-transferase alpha 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K-Keap1/Nrf2 pathway. Xiao Y, et al. J Int Med Res, 2019 Nov. PMID 31617428, Free PMC Article
    2. A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis. Chen H, et al. J Transl Med, 2019 Aug 23. PMID 31443720, Free PMC Article
    3. GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression. Xiao Y, et al. PLoS One, 2016. PMID 27602565, Free PMC Article
    4. Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5'-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1. Pulford DJ, et al. Biochem J, 1996 Aug 15. PMID 8761455, Free PMC Article
    5. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, et al. J Biol Chem, 1994 Aug 12. PMID 8051171

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GSTA3 inhibited hepatic stellate cell activation and liver fibrosis
      Title: A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis.
    2. The PI3K-KEAP1/Nrf2-GSTA3 signaling pathway is a possible mechanism of resisting external stimulation of renal fibrosis factors.
      Title: GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K-Keap1/Nrf2 pathway.
    3. Protein and mRNA expression of GSTA3 in UUO rats and NRK-52E cells were determined by Western blot and RT-PCR. siRNA and overexpression plasmid were transfected specifically to assess the role of GSTA3 in renal interstitial fibrosis
      Title: GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112704

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aflatoxin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S-transferase alpha-5
    Names
    GST A5-5
    GST Yc2
    glutathione S-transferase A3
    glutathione S-transferase Yc2 subunit
    NP_001009920.1
    NP_001153211.1
    NP_001273954.1
    XP_038939975.1
    XP_038939976.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009920.2 → NP_001009920.1  glutathione S-transferase alpha-5 isoform 1

      See identical proteins and their annotated locations for NP_001009920.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P46418, Q6LD91
      UniProtKB/TrEMBL
      A6JJ95
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    2. NM_001159739.2 → NP_001153211.1  glutathione S-transferase alpha-5 isoform 1

      See identical proteins and their annotated locations for NP_001153211.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P46418, Q6LD91
      UniProtKB/TrEMBL
      A6JJ95
      Related
      ENSRNOP00000074697.2, ENSRNOT00000088416.3
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    3. NM_001287025.1 → NP_001273954.1  glutathione S-transferase alpha-5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate 5' exon compared to variant 1 that results in the use of a downstream translation initiation codon. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K8Q5
      Conserved Domains (2) summary
      cd03208
      Location:36 → 170
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cl00388
      Location:1 → 32
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      31154989..31180653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084048.2 → XP_038939976.1  glutathione S-transferase alpha-5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JVT2, Q498T5
      Conserved Domains (2) summary
      cl00388
      Location:4 → 82
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
      cl02776
      Location:86 → 139
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. XM_039084047.2 → XP_038939975.1  glutathione S-transferase alpha-5 isoform X1

      UniProtKB/Swiss-Prot
      P46418, Q6LD91
      UniProtKB/TrEMBL
      A6JJ95
      Conserved Domains (2) summary
      cd03208
      Location:86 → 220
      GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
      cd03077
      Location:4 → 82
      GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46418.2 GenPept UniProtKB/Swiss-Prot:P46418

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