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    Caskin1 CASK interacting protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caskin1provided by RGD
    Official Full Name
    CASK interacting protein 1provided by RGD
    Primary source
    RGD:620191
    See related
    EnsemblRapid:ENSRNOG00000003195 AllianceGenome:RGD:620191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein domain specific binding activity. Involved in signal transduction. Located in cytoplasm. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 90.1), Testes (RPKM 27.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Caskin1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14016780..14037927)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13512684..13533380)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13853107..13874254)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog Neighboring gene TNF receptor associated factor 7 Neighboring gene uncharacterized LOC102551976 Neighboring gene small nucleolar RNA, C/D box 60

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK. Stafford RL, et al. Structure, 2011 Dec 7. PMID 22153505, Free PMC Article
    2. The molecular basis of the Caskin1 and Mint1 interaction with CASK. Stafford RL, et al. J Mol Biol, 2011 Sep 9. PMID 21763699, Free PMC Article
    3. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. Tabuchi K, et al. J Neurosci, 2002 Jun 1. PMID 12040031, Free PMC Article
    4. High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1. Balázs A, et al. FEBS J, 2009 Jul. PMID 19523119
    5. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. proline-rich region of Caskin1 is biochemically functional, as it interacts with the adaptor protein Abl-interactor-2.
      Title: High levels of structural disorder in scaffold proteins as exemplified by a novel neuronal protein, CASK-interactive protein1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic density assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    caskin-1
    Names
    cask-interacting protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080690.2 → NP_542421.2  caskin-1

      Status: VALIDATED

      Source sequence(s)
      AA819372, AF451975, CB733612, CB738051, CB800449, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q8VHK2
      UniProtKB/TrEMBL
      A0A8J8XK13
      Related
      ENSRNOP00000004486.2, ENSRNOT00000004486.7
      Conserved Domains (12) summary
      cd09497
      Location:473 → 538
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:540 → 609
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:472 → 534
      SAM; Sterile alpha motif
      cd12062
      Location:284 → 345
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:43 → 168
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:119 → 218
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:7 → 69
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:208 → 261
      Ank_5; Ankyrin repeats (many copies)
      pfam16600
      Location:373 → 421
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1368 → 1430
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:877 → 948
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:114 → 145
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14016780..14037927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245895.4 → XP_006245957.1  caskin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q8VHK2
      Conserved Domains (11) summary
      cd09497
      Location:480 → 545
      SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
      cd09498
      Location:547 → 616
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:479 → 541
      SAM; Sterile alpha motif
      cd12062
      Location:291 → 352
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:116 → 248
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:126 → 225
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:215 → 268
      Ank_5; Ankyrin repeats (many copies)
      pfam16600
      Location:380 → 428
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1375 → 1437
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:884 → 955
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:121 → 152
      ANK; ANK repeat [structural motif]

    2. XM_006245896.4 → XP_006245958.1  caskin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q8VHK2
      Conserved Domains (10) summary
      cd09498
      Location:483 → 545
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:487 → 542
      SAM; Sterile alpha motif
      cd12062
      Location:291 → 352
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:116 → 248
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:126 → 225
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:215 → 268
      Ank_5; Ankyrin repeats (many copies)
      pfam16600
      Location:380 → 428
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1304 → 1366
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:813 → 884
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:121 → 152
      ANK; ANK repeat [structural motif]

    3. XM_006245897.4 → XP_006245959.1  caskin-1 isoform X3

      UniProtKB/Swiss-Prot
      Q8VHK2
      UniProtKB/TrEMBL
      D3ZE17, F1LS31
      Related
      ENSRNOP00000039956.5, ENSRNOT00000043951.6
      Conserved Domains (11) summary
      cd09498
      Location:476 → 538
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      smart00454
      Location:480 → 535
      SAM; Sterile alpha motif
      cd12062
      Location:284 → 345
      SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
      cd00204
      Location:43 → 168
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:119 → 218
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:7 → 69
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:208 → 261
      Ank_5; Ankyrin repeats (many copies)
      pfam16600
      Location:373 → 421
      Caskin1-CID; Caskin1 CASK-interaction domain
      pfam16632
      Location:1297 → 1359
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:806 → 877
      Caskin-Pro-rich; Proline rich region of Caskin proteins
      sd00045
      Location:114 → 145
      ANK; ANK repeat [structural motif]

    4. XM_039085091.1 → XP_038941019.1  caskin-1 isoform X4

      Conserved Domains (5) summary
      PTZ00449
      Location:147 → 275
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      cd09498
      Location:1 → 56
      SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
      PRK12323
      Location:664 → 853
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam16632
      Location:815 → 877
      Caskin-tail; C-terminal region of Caskin
      pfam16907
      Location:324 → 395
      Caskin-Pro-rich; Proline rich region of Caskin proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHK2.1 GenPept UniProtKB/Swiss-Prot:Q8VHK2

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