Kansl1 KAT8 regulatory NSL complex subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kansl1provided by RGD
Official Full Name: KAT8 regulatory NSL complex subunit 1provided by RGD
Primary source: RGD:1311429
See related: EnsemblRapid:ENSRNOG00000053680 AllianceGenome:RGD:1311429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311429
Summary: Predicted to enable histone acetyltransferase binding activity. Predicted to be involved in regulation of mitochondrial transcription. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to human KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 168.0), Spleen (RPKM 137.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (89737637..89868620, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (89237667..89368735, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (92388045..92517449, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142713 (e-PCR)
- UniSTS:231960

RH141296 (e-PCR)
- UniSTS:223292

D10Chm231 (e-PCR)
- UniSTS:518218

D10Got135 (e-PCR)
- UniSTS:111703

AU025069 (e-PCR)
- UniSTS:115628

BF395827 (e-PCR)
- UniSTS:245428

BE120277 (e-PCR)
- UniSTS:247286

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone acetyltransferase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of mitochondrial transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: KAT8 regulatory NSL complex subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.