Mtmr7 myotubularin related protein 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtmr7provided by RGD
Official Full Name: myotubularin related protein 7provided by RGD
Primary source: RGD:1306608
See related: EnsemblRapid:ENSRNOG00000011420 AllianceGenome:RGD:1306608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable inositol bisphosphate phosphatase activity; phosphatidylinositol-3,5-bisphosphate phosphatase activity; and phosphatidylinositol-3-phosphate phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 210.5), Kidney (RPKM 48.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (58344755..58435682)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (51641267..51732212)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (54765214..54856255)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH130083 (e-PCR)
- UniSTS:213371

BE119707 (e-PCR)
- UniSTS:249253

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inositol bisphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol dephosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myotubularin-related protein 7

NP_001100782.2

EC 3.1.3.-

XP_038950459.1

EC 3.1.3.-

XP_038950460.1

EC 3.1.3.-

XP_038950461.1

EC 3.1.3.-

XP_063131499.1

EC 3.1.3.-

XP_063131500.1

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107312.3 → NP_001100782.2 myotubularin-related protein 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6AEZ2, A0A8I6GGY0

Related

ENSRNOP00000091098.1, ENSRNOT00000105685.2

Conserved Domains (2) summary

cd13344
Location:1 → 103

PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cd14583
Location:132 → 433

PTP-MTMR7; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

58344755..58435682

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275429.1 → XP_063131499.1 myotubularin-related protein 7 isoform X1

UniProtKB/TrEMBL

A0A0G2K1P1

Related

ENSRNOP00000071921.2, ENSRNOT00000086899.3
XM_063275430.1 → XP_063131500.1 myotubularin-related protein 7 isoform X2

UniProtKB/TrEMBL

A6JPV0
XM_039094531.2 → XP_038950459.1 myotubularin-related protein 7 isoform X3

UniProtKB/TrEMBL

A6JPV0

Conserved Domains (1) summary

cl28904
Location:5 → 291

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039094532.2 → XP_038950460.1 myotubularin-related protein 7 isoform X4

Conserved Domains (1) summary

cl28904
Location:1 → 212

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039094533.2 → XP_038950461.1 myotubularin-related protein 7 isoform X5

Conserved Domains (1) summary

cl28904
Location:17 → 205

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily