Dapk1 death associated protein kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dapk1provided by RGD
Official Full Name: death associated protein kinase 1provided by RGD
Primary source: RGD:1311629
See related: EnsemblRapid:ENSRNOG00000018198 AllianceGenome:RGD:1311629
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ATP binding activity; calmodulin binding activity; and syntaxin-1 binding activity. Predicted to be involved in several processes, including defense response to tumor cell; positive regulation of programmed cell death; and regulation of protein metabolic process. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in actin cytoskeleton and plasma membrane. Predicted to be part of DAPK1-calmodulin complex. Predicted to be active in several cellular components, including glutamatergic synapse; nucleus; and postsynaptic density. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 135.2), Kidney (RPKM 87.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (3935826..4096858, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (3930223..4090991, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (4297038..4454941, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DAPK1 mediates cognitive dysfunction and neuronal apoptosis in PSD rats through the ERK/CREB/BDNF signaling pathway.
Title: DAPK1 mediates cognitive dysfunction and neuronal apoptosis in PSD rats through the ERK/CREB/BDNF signaling pathway.
Mechanism of cAMP Response Element-binding Protein 1/Death-associated Protein Kinase 1 Axis-mediated Hippocampal Neuron Apoptosis in Rat Brain Injury After Cardiopulmonary Resuscitation.
Title: Mechanism of cAMP Response Element-binding Protein 1/Death-associated Protein Kinase 1 Axis-mediated Hippocampal Neuron Apoptosis in Rat Brain Injury After Cardiopulmonary Resuscitation.
CD93 hematopoietic stem cells improve diabetic wound healing by VEGF activation and downregulation of DAPK-1.
Title: CD93 hematopoietic stem cells improve diabetic wound healing by VEGF activation and downregulation of DAPK-1.
MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression.
Title: MicroRNA-98 attenuates cardiac ischemia-reperfusion injury through inhibiting DAPK1 expression.
data indicate that miR-141-3p may inhibit ovarian granulosa cell apoptosis via targeting DAPK1 and is involved in the etiology of polycystic ovary syndrome.
Title: MicroRNA-141-3p targets DAPK1 and inhibits apoptosis in rat ovarian granulosa cells.
Results show that the serine/threonine kinase death-associated protein kinase (DAPK) is involved in the signal transduction of neogenin.
Title: Neogenin regulates neuronal survival through DAP kinase.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH138879 (e-PCR)
- UniSTS:220966

RH141019 (e-PCR)
- UniSTS:223019

FH3103 (e-PCR)
- UniSTS:263756

BE105522 (e-PCR)
- UniSTS:245860

RH127309 (e-PCR)
- UniSTS:210619

RH138301 (e-PCR)
- UniSTS:220388

BE120223 (e-PCR)
- UniSTS:247273

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables syntaxin-1 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagic cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of NMDA receptor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of response to tumor cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DAPK1-calmodulin complex	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: death-associated protein kinase 1

NP_001100805.2

EC 2.7.11.1

XP_008769663.1

EC 2.7.11.1

XP_063132398.1

EC 2.7.11.1

XP_063132399.1

EC 2.7.11.1

XP_063132400.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107335.2 → NP_001100805.2 death-associated protein kinase 1

See identical proteins and their annotated locations for NP_001100805.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

B5DFH6, F1LNN8

Related

ENSRNOP00000062122.1, ENSRNOT00000066950.4

Conserved Domains (6) summary

PHA03095
Location:425 → 667

PHA03095; ankyrin-like protein; Provisional

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]

pfam13637
Location:379 → 431

Ank_4; Ankyrin repeats (many copies)

cl39094
Location:338 → 409

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

3935826..4096858 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276328.1 → XP_063132398.1 death-associated protein kinase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K5V8, B5DFH6
XM_063276329.1 → XP_063132399.1 death-associated protein kinase 1 isoform X1

UniProtKB/TrEMBL

A0A0G2K5V8, B5DFH6
XM_008771441.4 → XP_008769663.1 death-associated protein kinase 1 isoform X1

See identical proteins and their annotated locations for XP_008769663.1

UniProtKB/TrEMBL

A0A0G2K5V8, B5DFH6

Related

ENSRNOP00000073577.1, ENSRNOT00000080750.3

Conserved Domains (6) summary

smart00220
Location:13 → 275

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00204
Location:439 → 564

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd08782
Location:1308 → 1393

Death_DAPK1; Death domain found in death-associated protein kinase 1

cd14194
Location:7 → 275

STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

pfam12796
Location:449 → 541

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:412 → 442

ANK; ANK repeat [structural motif]
XM_063276330.1 → XP_063132400.1 death-associated protein kinase 1 isoform X2

UniProtKB/TrEMBL

B5DFH6