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    Elavl2 ELAV like RNA binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elavl2provided by RGD
    Official Full Name
    ELAV like RNA binding protein 2provided by RGD
    Primary source
    RGD:628611
    See related
    EnsemblRapid:ENSRNOG00000006853 AllianceGenome:RGD:628611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hub; Elav2
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of synapse assembly. Is active in cerebellar granule cell to Purkinje cell synapse. Orthologous to human ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 109.6), Testes (RPKM 10.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elavl2 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (111076705..111202341, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (105960872..106086463, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (109499410..109651829, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein S7, pseudogene 19 Neighboring gene uncharacterized LOC120103166 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions. Cheng N, et al. Biosci Rep, 2019 Nov 29. PMID 31696225, Free PMC Article
    2. AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors. Hambardzumyan D, et al. J Neurosci Res, 2009 May 1. PMID 19115409
    3. Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons. Fornaro M, et al. Ann Anat, 2007. PMID 17534028
    4. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Yamada T, et al. Neuron, 2014 Jul 2. PMID 24991957, Free PMC Article
    5. HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens. Bitel CL, et al. Mol Vis, 2010 Nov 4. PMID 21139978, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions.
      Title: Weighted gene co-expression network analysis reveals specific modules and hub genes related to neuropathic pain in dorsal root ganglions.
    2. The predominant expression of REST4, HuB/C/D and nPTB in post-mitotic fiber cells, together with miR-124 expression in vertebrate lenses, was shown.
      Title: HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens.
    3. findings indicated a specific developmental pattern of expression of HuB in the postnatal cerebellum; data suggest critical roles for HuB at the very earliest stages of neuronal differentiation, such as cell cycle exit
      Title: AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors.
    4. Part of a family of RNa-binding proteins found in sensory neurons.
      Title: Neuron-specific Hu proteins sub-cellular localization in primary sensory neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cerebellar granule cell to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cerebellar granule cell to Purkinje cell synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ELAV-like protein 2
    Names
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
    ELAV like neuron-specific RNA binding protein 2
    RNA binding protein HuB
    embryonic lethal, abnormal vision-like 2
    hu-antigen B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302217.2 → NP_001289146.1  ELAV-like protein 2

      See identical proteins and their annotated locations for NP_001289146.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A1B0GWQ5, A6JRF7, G3V6U4
      Related
      ENSRNOP00000009034.7, ENSRNOT00000009034.9
      Conserved Domains (1) summary
      TIGR01661
      Location:65 → 387
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      111076705..111202341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287239.1 → XP_063143309.1  ELAV-like protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8CH84

    2. XM_063287238.1 → XP_063143308.1  ELAV-like protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8CH84

    3. XM_063287232.1 → XP_063143302.1  ELAV-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWQ5
      Related
      ENSRNOP00000094592.1, ENSRNOT00000105492.2

    4. XM_063287235.1 → XP_063143305.1  ELAV-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWQ5, A6JRF7, G3V6U4

    5. XM_063287231.1 → XP_063143301.1  ELAV-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    6. XM_063287241.1 → XP_063143311.1  ELAV-like protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8CH84
      Related
      ENSRNOP00000076021.1, ENSRNOT00000093032.3

    7. XM_063287237.1 → XP_063143307.1  ELAV-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    8. XM_063287228.1 → XP_063143298.1  ELAV-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    9. XM_063287229.1 → XP_063143299.1  ELAV-like protein 2 isoform X4

      UniProtKB/Swiss-Prot
      Q8CH84

    10. XM_063287230.1 → XP_063143300.1  ELAV-like protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    11. XM_063287227.1 → XP_063143297.1  ELAV-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWQ5, A6JRF7, G3V6U4

    12. XM_063287226.1 → XP_063143296.1  ELAV-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    13. XM_063287240.1 → XP_063143310.1  ELAV-like protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8CH84

    14. XM_063287244.1 → XP_063143314.1  ELAV-like protein 2 isoform X6

      UniProtKB/Swiss-Prot
      Q8CH84

    15. XM_063287236.1 → XP_063143306.1  ELAV-like protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    16. XM_063287233.1 → XP_063143303.1  ELAV-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GWQ5

    17. XM_063287234.1 → XP_063143304.1  ELAV-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GWQ5, A6JRF7, G3V6U4

    18. XM_063287242.1 → XP_063143312.1  ELAV-like protein 2 isoform X7

    19. XM_063287243.1 → XP_063143313.1  ELAV-like protein 2 isoform X7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_173309.2: Suppressed sequence

      Description
      NM_173309.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH84.1 GenPept UniProtKB/Swiss-Prot:Q8CH84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials