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    Asap2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362719, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asap2provided by RGD
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 2provided by RGD
    Primary source
    RGD:1305263
    See related
    EnsemblRapid:ENSRNOG00000061519 AllianceGenome:RGD:1305263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ddef2
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Orthologous to human ASAP2 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 61.2), Lung (RPKM 44.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asap2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46386605..46549669)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (40658201..40821017)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43231178..43348606)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479348 Neighboring gene uncharacterized LOC134479349 Neighboring gene U6 spliceosomal RNA Neighboring gene integrin subunit beta 1 binding protein 1 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene cleavage and polyadenylation specific factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
    Names
    development and differentiation enhancing factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108704.3 → NP_001102174.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZL33, A0A8I5ZRL8
      Related
      ENSRNOP00000078581.2, ENSRNOT00000101416.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      46386605..46549669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113150.2 → XP_038969078.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

      Conserved Domains (1) summary
      cl12013
      Location:34 → 67
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. XM_063262069.1 → XP_063118139.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRL8

    3. XM_039113144.2 → XP_038969072.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRL8, A0A8I6GLF1
      Related
      ENSRNOP00000096020.2, ENSRNOT00000119000.2
      Conserved Domains (6) summary
      cd07642
      Location:34 → 248
      BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
      cd11966
      Location:942 → 997
      SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
      cd13251
      Location:297 → 403
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:586 → 618
      ANK; ANK repeat [structural motif]
      cd08849
      Location:419 → 541
      ArfGap_ASAP2; ArfGAP domain of ASAP2 (ArfGAP2 with SH3 domain, ANK repeat and PH domain-containing protein 2)
      pfam12796
      Location:589 → 675
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_063262070.1 → XP_063118140.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZRL8

    5. XM_063262071.1 → XP_063118141.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4

    6. XM_063262072.1 → XP_063118142.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5

      UniProtKB/TrEMBL
      A6HAV4

    RNA

    1. XR_010052116.1 RNA Sequence

      Related
      ENSRNOT00000086808.3
    Nucleotide Protein Strain
    Heading Accession and Version

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